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    PF-06869206
    PF-06869206

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4476
    CAS #: 2227425-05-8Purity ≥98%

    Description: PF-06869206 is a novel, potent, selective and orally bioavailable inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1) with an IC50 of 380 nM. Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal derangements associated with increased cardiovascular risk in chronic kidney disease-mineral and bone disorder (CKD-MBD). To date, only nonselective NaPi inhibitors have been described. The oral PK profile of inhibitor PF-06869206 in rodents allows for the exploration of the pharmacology of selective NaPi2a inhibition.

    References:  2018 Apr 12;9(5):440-445. 


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    PF-06869206

    Name: PF-06869206
    CAS#: 2227425-05-8
    Chemical Formula: C15H14ClF3N4O2
    Exact Mass: 374.0757
    Molecular Weight: 374.7482
    Elemental Analysis: C, 48.08; H, 3.77; Cl, 9.46; F, 15.21; N, 14.95; O, 8.54
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: PF-06869206; PF 06869206; PF06869206;
    IUPAC/Chemical Name: (S)-3-chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile
    InChi Key: ATFQBBCQZKVZJN-QMMMGPOBSA-N
    InChi Code: InChI=1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1
    SMILES Code: N#CC1=C(C(F)(F)F)N=C2C(NC(C)=C2Cl)=C1N3C[[email protected]@H](CO)OCC3


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