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    Nefopam HCl (Fenazoxine)
    Nefopam HCl (Fenazoxine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1655
    CAS #: 23327-57-3Purity ≥98%

    Description: Nefopam HCl (Fenazoxine) is a potent and centrally-acting but non-opioid analgesic drug by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake. It is widely used for the relief of moderate to severe pain as an alternative to opioid analgesic drugs. The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine.

    References: Br J Anaesth. 2008 Nov;101(5):610-7. 

    Related CAS #: 13669-70-0 (free base)   23327-57-3 (HCl)    46868-19-3 (N-Desmethylnefopam)

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    Molecular Weight (MW)289.8 
    FormulaC17H19NO.HCl 
    CAS No.23327-57-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL 
    Water: 21 mg/mL (72.5 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride

    InChi Key: CNNVSINJDJNHQK-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

    SMILES Code: CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1.[H]Cl

    Synonyms

    Leoplexamin; Nefopam HCl; Nefopam hydrochloride; Fenazoxine hydrochloride; Lenipan; Oxadol; Pallopikeron, Brand name Acupan


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    In Vitro

    In vitro activity: The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine.

    In VivoUsing the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. 
    Animal modelMice
    Formulation & Dosageintraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection
    References

    Br J Anaesth. 2008 Nov;101(5):610-7.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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