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    Nefopam HCl (Fenazoxine)
    Nefopam HCl (Fenazoxine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1655
    CAS #: 23327-57-3Purity ≥98%

    Description: Nefopam HCl (Fenazoxine; Leoplexamin; Lenipan; Oxadol; Pallopikeron; Acupan), the hydrochloride salt of nefopam, is a centrally-acting (non-opioid analgesic) painkiller that has been used to treat moderate pain such as muscle pain, joint pain, dental pain, or pain from cancer. It acts by blocking voltage-gated sodium channel and inhibition of serotonin, dopamine and noradrenaline reuptake.  

    References: Br J Anaesth. 2008 Nov;101(5):610-7. 

    Related CAS #: 13669-70-0 (free base)   23327-57-3 (HCl)    46868-19-3 (N-Desmethylnefopam)

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    Molecular Weight (MW)289.8 
    FormulaC17H19NO.HCl 
    CAS No.23327-57-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL 
    Water: 21 mg/mL (72.5 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine hydrochloride

    InChi Key: CNNVSINJDJNHQK-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

    SMILES Code: CN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3C1.[H]Cl

    Synonyms

    Leoplexamin; Nefopam HCl; Nefopam hydrochloride; Fenazoxine hydrochloride; Lenipan; Oxadol; Pallopikeron, Brand name Acupan


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    In Vitro

    In vitro activity: The mechanism of analgesia is not completely understood, it appears that nefopam is a centrally acting, non-opioid analgesic that inhibits reuptake of serotonin, norepinephrine, and dopamine.

    In VivoUsing the tail-flick and hot-plate assays, nefopam is tested for analgesic activity following intraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection in mice. Nefopam is one-third as potent as morphine on the hot-plate test, but does not affect the tail-flick. 
    Animal modelMice
    Formulation & Dosageintraperitoneal (i.p.), intracranial (i.c.) and intraspinal (i.s.) injection
    References

    Br J Anaesth. 2008 Nov;101(5):610-7.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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