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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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2g |
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10g |
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Purity: ≥98%
Oxcarbazepine (also known as GP47680; GP-47680, Timox, Trileptal), a sodium channel protein inhibitor, is an anticonvulsant drug used in the treatment of epilepsy. It inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. It is an anticonvulsant drug primarily used in the treatment of epilepsy. There is some evidence for oxcarbazepine as a mood-stabilizing agent and thus, it can be used as add-on therapy for bipolar disorder in patients that have failed or are unable to tolerate approved treatments.
ln Vitro |
Glioblastoma cell growth is markedly inhibited by oxcarbazepine, which achieves IC50 at therapeutic dosages. Oxcarbazepine screening in U87 and T98 cell lines yielded IC50 values of 12.35 and 9.45 μg/mL, respectively[2].
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ln Vivo |
Oxcarbazepine has been shown to protect mice and rats against shock-induced generalized tonic-clonic seizures with oral ED50 values ranging from 13.5 to 20.5 mg/kg. Rats given oxcarbazepine on a daily basis for four weeks showed no signs of tolerance to this anticonvulsant action.
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Cell Assay |
Cell viability assay [2]
Cell Types: Human glioma cell lines U-87 MG and T98G Tested Concentrations: 2.5, 5, 10, 20 and 40 μg/mL Incubation Duration: 72 hrs (hours) Experimental Results: Growth inhibition of T98G cell line per The individual concentrations are 17.7±4.1% (2.5 μg/mL), 21.1±3.6% (5 μg/mL), 53.6±14.2% (10 μg/mL), 82.2±2.3% (20 μg/mL) and 85.0± 2.3 % (40 μg/ml). The growth inhibition of U-87 MG cell line at each concentration was -1.7±5.1% (0.008 μg/mL), 5.3±2.4% (0.08 μg/mL), 3.5±7.4% (0.8 μg/mL), 0.3± 9.2 % (16 μg/ml) and -4.2±9.6% (40 μg/ml). |
References |
[1]. Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9.
[2]. Ching-Yi Lee,et al. The effects of antiepileptic drugs on the growth of glioblastoma cell lines. J Neurooncol. 2016 May;127(3):445-53. [3]. M Schmutz, et al. Oxcarbazepine: preclinical anticonvulsant profile and putative mechanisms of action. Epilepsia. 1994;35 Suppl 5:S47-50. |
Molecular Formula |
C15H12N2O2
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Molecular Weight |
252.27
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CAS # |
28721-07-5
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SMILES |
O=C1C2=C([H])C([H])=C([H])C([H])=C2N(C(N([H])[H])=O)C2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
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InChi Key |
QZAQRPLWHYVQMM-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C15H12N2O2/c16-15(18)12-9-10-5-1-3-7-13(10)17(19)14-8-4-2-6-11(12)14/h1-6,8-9H,7H2,(H2,16,18)
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Chemical Name |
5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.9640 mL | 19.8200 mL | 39.6401 mL | |
5 mM | 0.7928 mL | 3.9640 mL | 7.9280 mL | |
10 mM | 0.3964 mL | 1.9820 mL | 3.9640 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.