Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V23729 | Lappaconitine | 32854-75-4 | Lappaconitine is a novel and potent cardiac Na+ channel blocker. |
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V1651 | Levobupivacaine HCl (S-Bupivacaine) | 27262-48-2 | Levobupivacaine HCl [also known as (S)-(-)-Bupivacaine; Chirocaine, Novabupi], the hydrochloride salt of Levobupivacaine which is the pure S(-)-enantiomer of bupivacaine, is a reversible neuronal sodium channel inhibitor. |
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V73680 | Licarbazepine-d3 (BIA 2-005-d3; GP 47779-d3) | 1189917-36-9 | Licarbazepine-d3 is the deuterium labelled form of Licarbazepine . |
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V15445 | Lidocaine Hydrochloride Monohydrate | 6108-05-0 | Lidocaine hydrochloride monohydrate (also known as Alphacaine; Lignocaine) is a potent and selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. |
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V73665 | Lu AE98134 | 849000-18-6 | Lu AE98134 is an activator of voltage-gated sodium channels and serves as a partially selective activator of Nav1.1 channels. |
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V80657 | m3-Huwentoxin IV (m3-HwTx-IV) | m3-Huwentoxin IV (m3-HwTx-IV) is a potent NaV inhibitor (antagonist) with IC50 of 3.3, hNaV1.7, hNaV1.6, hNaV1.3, hNaV1.1, hNaV1.2 and hNaV1.4 respectively. | |
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V73719 | Mambalgin 1 | 1609937-15-6 | Mambalgin-1 is a toxin extracted from the venom of the black mamba snake. |
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V80675 | Mambalgin 1 TFA | Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC50s are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). | |
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V80676 | Mambalgin-2 (Mamb-2) | Mambalgin-2 (Mamb-2) is an inhibitor (blocker/antagonist) of acid-sensitive ion channels (ASICs) and a venom peptide obtained from the venom of the African black mamba. | |
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V80677 | Mambalgin-3 | Mambalgin-3 is an acid-sensitive ion channel 1 (ASIC1) inhibitory peptide that may be utilized in analgesic research. | |
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V73678 | Mepivacaine | 96-88-8 | Mepivacaine is an amide-type agent that temporarily causes localized unconsciousness. |
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V73710 | Mepivacaine-d3 | 1346597-90-7 | Mepivacaine-d3 is the deuterium labelled form of Mepivacaine. |
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V73715 | Methocarbamol-d3 (Methocarbamol d3) | 1346600-86-9 | Methocarbamol-d3 is the deuterated form of Methocarbamol. |
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V1657 | Mexiletine HCl (KOE-1173) | 5370-01-4 | Mexiletine HCl (Mexitil, Mexiletene, KO-1173, KO 1173; KO1173),the hydrochloride salt ofMexiletine, is an anti-arythmic drug of the Class IB group approved for use in the treatment of abnormal heart rhythms. |
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V80772 | mHuwentoxin-IV | mHuwentoxin-IV is a naturally modified Huwentoxin-IV. | |
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V80782 | mitTX | MitTx is a complex formed by MitTx-α and MitTx-β. | |
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V80783 | MitTx-alpha | MitTx-alpha is a subunit of MitTx. | |
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V73727 | NaV1.2/1.6 channel blocker-1 | 1199944-04-1 | NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, inhibiting rNaV1.6 and hNaV1.2 with IC50s of 9.8 and 24.4 μM, respectively. |
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V79963 | Nav1.3 channel inhibitor 1 | Nav1.3 channel inhibitor 1 (compound 15b) is a state-dependent voltage-gated sodium channel Nav1.3 inhibitor (IC50=20 nM). | |
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V33122 | Nav1.7 inhibitor | 1355631-24-1 | Nav1.7 inhibitor is a novel and potent Voltage-gated sodium channel inhibitor with potential usefulness in pain therapy and as a local anaesthetic. |
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