Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V13541 | QX-314 Br | 24003-58-5 | QX-314 Br is a novel intracellular blocker of NaVchannels1-4and a membrane impermeable quaternary analogue of lidocaine, a blocker of voltage-activated Na+ channels. |
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V3620 | Raxatrigine | 934240-30-9 | Raxatrigine (also known as GSK1014802 and CNV-1014802) is a novel, potent small molecule state-dependent sodium channel blocker, the Nav1.7 sodium channel inhibitor. |
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V7461 | Raxatrigine HCl (GSK1014802, CNV1014802) | 934240-31-0 | Raxatrigine (also known as GSK-1014802 and CNV-1014802) is a novel, potent small molecule state-dependent sodium channel blocker, the Nav1.7 sodium channel inhibitor. |
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V73674 | Relutrigine (PRAX-562) | 2392951-29-8 | Relutrigine (PRAX-562) is an orally bioactive, persistent sodium channel inhibitor. |
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V11111 | Ropivacaine HCl hydrate | 132112-35-7 | Ropivacaine HCl hydrate is a novel and potent sodium channelblockerused as ananaesthetic agent, blocking neuropathic pain. |
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V1643 | Rufinamide (CGP 33101; RUF 331) | 106308-44-5 | Rufinamide (also known as CGP-33101; E-2080; RUF-331; BANZEL; Inovelon)is a voltage-gated sodium channel blocker approved as an antiepilepic agent for seizure treatment. |
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V3654 | RY785 | 1393748-80-5 | RY785 is a potent and specific voltage-gated potassium (KV2) channel inhibitor (antagonist) with IC50 of 0.05 μM for KV2.2. |
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V81377 | Scorpion toxin Tf2 | Scorpion toxin Tf2 is a β-scorpion toxin first discovered in the venom of the Brazilian scorpion Tityus fasciolatus. | |
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V73684 | Sodium Channel inhibitor 4 | 587843-16-1 | Sodium Channel inhibitor 4 is a sodium channel inhibitor. |
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V73666 | Suzetrigine (VX-548) | 2649467-58-1 | Suzetrigine is a sodium channel protein type 10 subunit alpha blocker. |
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V81512 | Tap1a (Theraphotoxin-Tap1a; TRTX-Tap1a; µ/ω-TRTX-Tap1a) | Tap1a (Theraphotoxin-Tap1a) is a spider venom peptide that can inhibit sodium channels, with IC50s of 80 nM and 301 nM for Nav1.7 and Nav1.1, respectively. | |
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V73714 | Taplucainium chloride | 2489565-37-7 | Taplucainium chloride is a sodium channel blocker. |
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V73673 | TC-N 1752 | 1211866-85-1 | TC-N 1752 is a potent and orally bioactive Nav1.7 inhibitor (antagonist) with IC50s of 0.17 μM and 0.3 μM for hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. |
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V77572 | Tiludronate-d5 sodium (Tiludronic acid-d5 (sodium)) | Tiludronate-d5 (sodium)m is the deuterium labelled form of Tiludronate disodium. | |
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V1658 | Tolperisone HCl (AV 650) | 3644-61-9 | Tolperisone HCl (AV650; AV-650; N553;Midocalm; Muscalm; Mydocalm),the hydrochloride salt of tolperisone, is an ion channel blocker and centrally-acting muscle relaxant. |
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V73661 | TPC2-A1-P | 2804595-86-4 | TPC2-A1-P is a potent membrane-permeable (penetrable) two-pore channel 2 (TPC2) agonist (EC50=10.5 μM) that acts by mimicking the physiological effects of PI(3,5)P2. |
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V1668 | Triamterene (SKF8542) | 396-01-0 | Triamterene (formerly SKF-8542; SKF8542; BRN-0266723; Dyrenium;Diucelpin; Diurene)is a diuretic commonly used in combination with thiazide diuretics (e. |
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V5042 | Veratramine (NSC17821; NSC23880) | 60-70-8 | Veratramine (formerly known as NSC17821 and NSC23880) is a novel, potent and selective natural modulator of AP-1 which is useful as a signal transduction inhibitor for treating tumors. |
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V73725 | VGSC blocker-1 | 2230472-55-4 | VGSC blocker 1 is a potent small molecule blocker of the neonatal isoform of the VGSC subtype Nav1.5 (nNav1.5). |
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V73701 | VGSCs-IN-1 | 1204296-79-6 | VGSCs-IN-1 (compound 14) is a 2-piperazine analog of Riluzole and a human voltage-gated sodium channel (VGSC) inhibitor. |
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