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    PF-06305591
     PF-06305591

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4453
    CAS #: 1449473-97-5Purity ≥98%

    Description: PF-06305591 is a novel, potent and highly selective blocker of voltage gated sodium channel NaV1.8 with an IC50 of 15 nM and with excellent ADME and safety profiles. The voltage gated sodium channel NaV1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole NaV1.8 blockers. Subsequent optimization allowed the identification of compound 9, PF-06305591, as a potent, highly selective blocker with an excellent preclinical in vitro ADME and safety profile.

    References:  2019 Jan 1;27(1):230-239. 


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     PF-06305591

    Molecular Weight: 274.36
    Formula: C₁₅H₂₂N₄O
    CAS No.: 1449473-97-5
    SMILES: CC(C)(C)C1=CC=C(NC([[email protected]]([[email protected]@H](C)C(N)=O)N)=N2)C2=C1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationPF-06305591; PF 06305591; PF06305591


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