Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V4549 | GNE-131 | 1629063-81-5 | GNE-131 is a novel, potent and selective inhibitor of human sodium channelNaV1.7, with anIC50of 3 nM. |
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V73687 | GpTx-1 | 1661050-12-9 | GpTx-1 is a potent and specific NaV1.7 antagonist (inhibitor) with IC50 of 10 nM. |
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V2888 | GS967 | 1262618-39-2 | GS967 (also known as GS-458967) is a novel, potent, and selective sodium channel inhibitor exhibiting potent antiarrhythmic effects in various in vitro and in vivo models. |
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V73668 | GX-201 | 1788071-27-1 | GX-201 is a selective NaV1.7 inhibitor (antagonist) with IC50 of <3.2 nM for hNaV1.7. |
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V73713 | Hainantoxin-III | 1809149-40-3 | Jingzhaotoxin-V is a bioactive peptide that can inhibit potassium current in Xenopus laevis oocytes, with IC50 of 604.2 nM. |
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V73685 | Hainantoxin-IV (HNTX-IV) | 651782-02-4 | Hainantoxin-IV is a specific antagonist of sodium channels targeting tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. |
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V79806 | Hm1a | Hm1a is a disulfide-rich spider venom peptide and a NaV1.1 activator. | |
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V79651 | htK | GrTx1 is a bioactive peptide toxin originally extracted from the venom of the Grammostola rosea spider. | |
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V73693 | Huwentoxin-IV | 526224-73-7 | Huwentoxin-IV is a specific sodium channel blocker that can inhibit neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM respectively. |
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V80330 | Huwentoxin-IV TFA | Huwentoxin-IV TFA is a specific sodium channel blocker that can inhibit neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC50s of 26, 150, 338 and 400 nM respectively. | |
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V1663 | Ibutilide Fumarate (U70226E) | 122647-32-9 | Ibutilide fumarate (formerly known as U 70226 E;U-70226-E; U-70226E), the fumarate salt ofIbutilide, is aClass III antiarrhythmic agent that has been used for treating acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current. |
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V2997 | ICA-121431 | 313254-51-2 | ICA-121431 is a potent, highly selectivesmall molecule inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels with IC50 of 19 nM. |
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V73669 | Indoxacarb ((±)-Indoxacarb; DPX-JW062) | 144171-61-9 | Indoxacarb ((±)-Indoxacarb; DPX-JW062) is a broad-spectrum oxadiazine insecticide with high insecticidal activity and low mammalian toxicity. |
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V80441 | Jingzhaotoxin XI (JZTX-XI) | Jingzhaotoxin XI (JZTX-XI) is a sodium conductance inhibitor (antagonist) with IC50 of 124 nM. | |
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V80427 | Jingzhaotoxin-34 | Jingzhaotoxin-34 is a 35-residue polypeptide and a neurotoxin. | |
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V80428 | Jingzhaotoxin-II | Jingzhaotoxin-II is a neurotoxin consisting of 32 amino acid (AA) residues such as two acidic residues and two basic residues. | |
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V73688 | Jingzhaotoxin-III (β-TRTX-Cj1α) | 925463-91-8 | Jingzhaotoxin-III is a potent and specific Nav1.5 channel blocker with IC50 of 348 nM and has no effect on other sodium channel subtypes. |
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V80443 | Jingzhaotoxin-IX | Jingzhaotoxin-IX is a C-terminal amidated peptide consisting of 35 amino acid (AA) residues and is a neurotoxin. | |
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V80444 | Jingzhaotoxin-V | Jingzhaotoxin-V is a 29-residue polypeptide extracted from the venom of the Chilobrachys jingzhao spider. | |
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V73692 | KC 12291 hydrochloride | 181936-98-1 | KC 12291 HCl is an orally bioactive voltage-gated sodium channel (VGSC) blocker. |
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