Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73612 | Pandinotoxin Kα | 185529-64-0 | Pandininotoxin Kα is extracted from the venom of Pandinus imperator and is an inhibitor (blocker/antagonist) of type A potassium channel (potassium channel). |
|
V73626 | Patiromer | 1208912-84-8 | Patiromer is an orally bioactive and potent hyperkalemia inhibitor, potassium binder. |
|
V73625 | PE 22-28 | 1801959-12-5 | PE 22-28 is a TREK-1 inhibitor (antagonist) with IC50 of 0.12 nM. |
|
V73638 | Phrixotoxin 2 | 741738-57-8 | Phrixotoxin 2 is a selective KV4.2 and KV4.3 channel blocker. |
|
V73632 | Phrixotoxin-1 | 221872-97-5 | Phrixotoxin 1 is derived from the venom of the wolf spider Phrixotrichus auratus and is a specific peptide inhibitor of the Kv4 potassium channel. |
|
V29082 | Pinacidil monohydrate | 85371-64-8 | Pinacidil (P-1134) monohydrate, an anti-hypertensive (blood pressure lowering) drug, is a potassium channel activator. |
|
V1686 | Probenecid (Benemid) | 57-66-9 | Probenecid (Benemid; Probecid;Benecid; Benuryl; Probenecid Martec; Probalan)is an OAT (organic anion transport) inhibitor which has been used as a medication to increase uric acid excretion in the urine. |
|
V8951 | Psora-4 | 724709-68-6 | Psora-4 is a novel, potent and selective small-molecule inhibitor ofvoltage-gated potassium channels - Kv1.3 with EC50of 3 nM. |
|
V7338 | Quinine | 130-95-0 | Quinine is a naturally occuring anti-malaria agent which acts as apotassium channelinhibitor with anIC50of 169 μM, also has antipyretic (fever-reducing), analgesic (painkilling), anti-inflammatory properties and a bitter taste. |
|
V1675 | Repaglinide (AG-EE 623ZW) | 135062-02-1 | Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm)is a potent and short-acting potassium channel blocker with antidiabetic activity. |
|
V73588 | Rimtuzalcap (CAD-1883) | 2167246-24-2 | Rimtuzalcap (CAD-1883) is a first-in-class, selective PAM (positive allosteric modulator) of small conductance calcium-activated potassium channels (SK channels). |
|
V73653 | ROMK-IN-32 | 1914944-54-9 | ROMK-IN-32 is an inhibitor (blocker/antagonist) of renal outer medullary potassium channels (ROMK) with IC50 of 35 nM. |
|
V73602 | RU-TRAAK-2 | 1210538-56-9 | RU-TRAAK-2 is a fully reversible TRAAK inhibitor. |
|
V73614 | RuBi-4AP | 851956-02-0 | RuBi-4AP is an analogue of 4-aminopyridine (4AP) and a cage Kv channel blocker. |
|
V1685 | SB705498 | 501951-42-4 | SB-705498 (SB705498; SB 705498) is an orally bioavailable and competitive antagonist of the capsaicin-mediated activation of TRPV1 (transient receptor potential vanilloid 1) receptors with important biological activity. |
|
V3851 | Sematilide HCl | 101526-62-9 | Sematilide (formerlyknown as CK-1752) isa novel class III antiarrhythmic agent. |
|
V14637 | Senicapoc (ICA17043) | 289656-45-7 | Senicapoc, formerly known as ICA-17043, is a highly potent Gardos Channel (Ca2+-activated K+ channel; KCa3.1) inhibitor/blocker with an IC50 of 11 nM, and with the potential for the treatment of a subset of Hereditary Xerocytosis caused by mutations in the Gardos channel. |
|
V14863 | SKA-31 | 40172-65-4 | SKA-31 is a potassium channel activator. |
|
V81401 | Slotoxin | Slotoxin is a bioactive peptide extracted from the venom of the Hoffmann's scorpion Centruroides noxius, which blocks high-conductance calcium-activated potassium channels (potassium channel) with a Kd of 1.5 nM [1]. | |
|
V71346 | Sotalol | 3930-20-9 | Sotalol is an orally bioactive, non-selective beta-adrenoceptor blocker. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
