Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3523 | Naminidil | 220641-11-2 | Naminidil (BMS 234303-01) is a novel and potentcyanoguanidineKATPopener (ATP-Sensitive Potassium Channel Vasodilator). |
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V0198 | Nateglinide (Starlix; A4166) | 105816-04-4 | Nateglinide (formerly A-4166; trade names: Fastic, Starlix), a meglitinide analog,is a potent and orally bioavailableantihyperglycemic medication used for treating type 2 diabetes [non-insulin-dependent diabetes mellitus (NIDDM)]. |
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V1676 | Nicorandil (SG-75) | 65141-46-0 | Nicorandil (formerly RP46417; SG-75; SG75; RP-46417; Dancor and Adancor) is a potassium channel activator that has been approved as a vasodilatory drug to treat angina. |
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V73620 | Nicorandil-d4 (Nicorandil d4) | 1132681-23-2 | Nicorandil-d4 is the deuterium labelled form of Nicorandil. |
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V41791 | Nifekalant hydrochloride (MS-551) | 130656-51-8 | Nifekalant hydrochloride (MS-551) is an IKr potassium channel blocker belonging to the class III antiarrhythmic agentwith an IC50 of 10 µM. |
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V4873 | Nigericin sodium | 28643-80-3 | Nigericin sodium, the sodium salt of nigericin which is an antibiotic isolated fromStreptomyces hygroscopicus,is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. |
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V73657 | Noxiustoxin | 85205-49-8 | Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius that blocks voltage-dependent potassium channels (Kv1.3, IC50=360 nM) and calcium-activated potassium channels. |
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V11738 | NS-11021 | 956014-19-0 | NS-11021 is a novel, potent and selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). |
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V2831 | NS-1643 | 448895-37-2 | NS1643 is a novel and potent human ether-a-go-go related gene (hERG) KV11 channel activator with EC50 of 10.5 μM. |
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V21754 | NS-5806 | 426834-69-7 | NS-5806 (NS5806) is a novel and potent potassium currentKV4.3 channel activator whichincreases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. |
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V2809 | NS1619 | 153587-01-0 | NS-1619 is a selective activator of the large conductance Ca2+-activated K+-channel (BKCa, KCa1.1). |
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V73591 | NS19504 | 327062-46-4 | NS19504 is a Ca2+-activated K+ channel (BK channel) activator (EC50=11.0 µM) that has a relaxing effect on spontaneous phasic contractions of bladder smooth muscle. |
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V26675 | NS309 | 18711-16-5 | NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). |
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V26676 | NS3623 | 343630-41-1 | NS3623 (NS-3623) is a novel and potent (hERG) and KV4.3 channel activator withantiarrhythmic effects. |
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V2816 | NS6180 | 353262-04-1 | NS6180 is a novel potent and selective KCa3.1 channel inhibitor with IC50 of 9 nM. |
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V73654 | OSK-1 | 183815-75-0 | OSK-1 is an effective Kv channel blocker, with IC50s of 0.6 nM, 5.4 nM and 0.014 nM for Kv1.1, Kv1.2 and Kv1.3 respectively. |
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V70540 | Oxybutynin-d11 chloride (oxybutynin d11 (chloride)) | 1185151-95-4 | Oxybutynin-d11 (chloride) is the deuterated form of Oxybutynin chloride. |
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V73630 | P-CAB agent 2 | 1978371-23-1 | P-CAB agent 2 is a potent and orally bioactive potassium-competitive acid blocker and gastric acid secretion inhibitor. |
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V73610 | P-CAB agent 2 hydrochloride | 2209911-80-6 | P-CAB agent 2 HCl is a potent and orally bioactive potassium-competitive acid blocker and gastric acid secretion inhibitor. |
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V18696 | PA-6 | 500715-03-7 | PA-6 is a selective and potent IK1 (inward rectifier potassium current) inhibitor that terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. |
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