| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| Other Sizes |
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Purity: ≥98%
Quinine is a naturally occuring anti-malaria agent which acts as a potassium channel inhibitor with an IC50 of 169 μM, also has antipyretic (fever-reducing), analgesic (painkilling), anti-inflammatory properties and a bitter taste. It is a stereoisomer of of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. Quinine prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus.
| ln Vitro |
In the human liver cancer HepG2 cell line, quinine (150 μM, 30 min) suppresses the growth and cytostatic effects of dengue virus [1]. In the human liver cancer HepG2 cell line, quinine (37.5-150 μM, 24 hours) greatly lowers viral DENV RNA and protein levels in a dose-dependent manner [1].
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| ln Vivo |
Swiss albino mice treated with quinine (gavated, 12 or 15 mg/kg, weekly, 16 weeks) show some inhibitory effects against skin cancer [2]. In the testicular tissue of adult male albino rats, quinine (gavage, 10 mg/kg, daily, 8 weeks) reduces the activity of the antioxidant defense system's SOD, CAT, and GSH enzymes [3].
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| Cell Assay |
Cell Proliferation Assay[1]
Cell Types: Human hepatocarcinoma cell line (HepG2) Tested Concentrations: 150 μM Incubation Duration: 30 min Experimental Results: Inhibited DENV virus replication with 19% yield compared to untreated. decreased DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner. |
| Animal Protocol |
Animal/Disease Models: Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Doses: 12 mg/kg, 15 mg/kg Route of Administration: po (oral gavage); every week; 16 weeks Experimental Results: Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg. |
| References |
[1]. Jhanwar, Deepika，et al. Chemoprevention of DMBA induced skin carcinogenesis in swiss albino mice by quinine sulfate.(2016): 2636-2640.
[2]. Shilu Malakar，et al. Drug repurposing of quinine as antiviral against dengue virus infection. Virus Res. 2018 Aug 15;255:171-178. doi: 10.1016/j.virusres.2018.07.018. Epub 2018 Jul 25. [3]. Ebenezer O Farombi, et al. Quercetin protects against testicular toxicity induced by chronic administration of therapeutic dose of quinine sulfate in rats. J Basic Clin Physiol Pharmacol. 2012 Feb 27;23(1):39-44. [4]. Jane Achan , et al. Quinine, an Old Anti-Malarial Drug in a Modern World: Role in the Treatment of Malaria. Malar J. 2011 May 24;10:144. [5]. Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172(17):4355-63. |
| Molecular Formula |
C20H24N2O2EXACTMASS
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|---|---|
| Molecular Weight |
324.42
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| CAS # |
130-95-0
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| Related CAS # |
Quinine hydrochloride dihydrate;6119-47-7;Quinine sulfate hydrate;6119-70-6;Quinine hemisulfate;804-63-7;Quinine sulfate;549-56-4;Quinine hydrobromide;549-49-5;Quinine dihydrochloride;60-93-5;Quinine hemisulfate hydrate;207671-44-1
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| SMILES |
COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O
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| InChi Key |
LOUPRKONTZGTKE-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3
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| Chemical Name |
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
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| Synonyms |
Quinine Chinin Chininum 6'-Methoxycinchonidine (8S,9R)-Quinine Qualaquin Odan Brand of Quinine Sulfate Plough Brand of Quinine Sulfate Prosana Brand of Quinine Bisulfate Quinamm Quinbisan Quinbisul Quindan
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage. (2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~308.24 mM)
H2O : ~0.1 mg/mL (~0.31 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.71 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.71 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (7.71 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0824 mL | 15.4121 mL | 30.8242 mL | |
| 5 mM | 0.6165 mL | 3.0824 mL | 6.1648 mL | |
| 10 mM | 0.3082 mL | 1.5412 mL | 3.0824 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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