| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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| Other Sizes |
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Purity: ≥98%
Repaglinide (AG-EE388 ZW; AG-EE-623 ZW, Prandin, GlucoNorm, Surepost, NovoNorm) is a potent and short-acting potassium channel blocker with antidiabetic activity. It can lower blood glucose by stimulating the release of insulin from the pancreas. Repaglinide is an approved antidiabetic drug belonging to the meglitinide class of medications, and was invented in 1983. Repaglinide is an oral medication used for the treatment of type 2 diabetes mellitus. The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas.
| ln Vitro |
Repaglinide decreases postprandial glucose levels by boosting the early phase of insulin secretion and increasing the total quantity of insulin secreted[1].
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| ln Vivo |
Repaglinide (AG-EE 623ZW) has a t1/2 of less than an hour and is absorbed very quickly (tmax less than an hour). Repaglinide is also inactivated in the liver and eliminated through the bile in more than 90% of cases. Repaglinide (1 mg/kg po) in a rat model of type 2 diabetes (low-dose streptozotocin) is an effective (P<0.001) insulin-releasing drug.
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| Animal Protocol |
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| References |
[1]. Wang LC, et al. Characteristics of repaglinide and its mechanism of action on insulin secretion in patients with newly diagnosed type-2 diabetes mellitus.Medicine (Baltimore). 2018 Sep;97(38):e12476.
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| Molecular Formula |
C27H36N2O4
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| Molecular Weight |
452.59
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| CAS # |
135062-02-1
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| Related CAS # |
Repaglinide-d5;1217709-85-7
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| SMILES |
O=C(C([H])([H])C1C([H])=C([H])C(C(=O)O[H])=C(C=1[H])OC([H])([H])C([H])([H])[H])N([H])[C@@]([H])(C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])C1=C([H])C([H])=C([H])C([H])=C1N1C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
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| InChi Key |
FAEKWTJYAYMJKF-QHCPKHFHSA-N
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| InChi Code |
InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1
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| Chemical Name |
2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2095 mL | 11.0475 mL | 22.0951 mL | |
| 5 mM | 0.4419 mL | 2.2095 mL | 4.4190 mL | |
| 10 mM | 0.2210 mL | 1.1048 mL | 2.2095 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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