Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71322 | Sotalol-d6 (MJ 1999-d6) | 1246912-17-3 | Sotalol-d6 is the deuterium labelled form of Sotalol. |
|
V76488 | Spadin TFA | Spadin TFA, a natural peptide extracted from a propeptide released in the blood, is a potent TREK-1 channel blocker with IC50 of 10 nM. | |
|
V73611 | Spinoxin (Potassium channel toxin alpha-KTx 6.13; SPX; α-KTx6.13) | 752984-66-0 | Spinoxin, extracted from the venom of the scorpion Heterometrus spinifer, is a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. |
|
V15184 | SPS-4251 | 870653-45-5 | SPS-4251 [PAP-1; SPS4251; 5-(4-Phenoxybutoxy)psoralen] is a novel and potent KCNA3 channel blocker (inhibitor ofKv1.3, voltage-gated K+ channel) with the potential to be usedin treatment of multiple sclerosis. |
|
V81436 | Ssm spooky toxin (SsTx Toxin) | Ssm Spooky Toxin is extracted from Scolopendra mutilans and displays lethal toxicity in the blood and respiratory system by effectively inhibiting KCNQ (voltage-gated potassium channel family 7) channels. | |
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V73649 | Stromatoxin 1 | 741738-59-0 | Stromatoxin 1 is a potassium channel inhibitor, a peptide extracted from tarantulas. |
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V81501 | Tamapin | Tamapin is a venom peptide that targets small conductance Ca(2+)-activated K(+) (SK) channels. | |
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V81502 | Tamapin TFA | Tamapin TFA is a venom peptide that targets small conductance Ca(2+)-activated K(+) (SK) channels. | |
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V81556 | Tertiapin LQ | Tertiapin LQ is a specific and reversible inhibitor of the renal outer medullary potassium ROMK1 (Kir1.1) channel. | |
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V81557 | Tertiapin-RQ | Tertiapin-RQ is an inward rectifier K+ channel blocker peptide with antidepressant effects. | |
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V73585 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. |
|
V73651 | Tipepidine | 5169-78-8 | Tipepidine reversibly inhibits dopamine D2 receptor-mediated GIRK currents (IDA(GIRK)), thereby activating VTA dopamine neurons, with IC50 of 7.0 μM for IDA(GIRK). |
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V73635 | tKIM | 326921-25-9 | TKIM is a TREK-1 channel inhibitor (antagonist) with IC50 of 2.96 μM. |
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V0192 | Tolbutamide (HLS-831) | 64-77-7 | Tolbutamide (also known as HLS 831; trade names: Artosin, Diabetol, Orinase),a sulfonylurea analog,is a potent and selectiveinhibitor of potassium channel used as an oral blood-glucose-lowering/hypoglycemicmedication. |
|
V1674 | TRAM-34 | 289905-88-0 | TRAM-34 (TRAM34;TRAM 34 Triarylmethane-34)is an inhibitor of Ca2+-activated K+ channel (IKCa1, KCa3.1) with important biological activity. |
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V73633 | Tripamide | 73803-48-2 | Tripamide is an orally bioactive sulfonamide diuretic anti-hypertensive (blood pressure lowering) agent. |
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V73634 | TWIK-1/TREK-1-IN-1 | 1440532-30-8 | TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor (blocker/antagonist) of the TWIK-related potassium channel (Potassium Channel) TREK-1. |
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V73621 | TWIK-1/TREK-1-IN-2 | 1440532-32-0 | TWIK-1/TREK-1-IN-2 (Compound 2g) is a TWIK-1/TREK-1 inhibitor. |
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V73617 | TWIK-1/TREK-1-IN-3 | 1440532-33-1 | TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor (blocker/antagonist) of TWIK-related potassium channel (Potassium Channel) TREK-1. |
|
V1684 | Verdinexor (KPT-335) | 1392136-43-4 | This product has been discontinued. |
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