Almost all living things contain potassium channels, which are the most common type of ion channel. They build pores across cell membranes that are selective for potassium. The majority of cell types contain potassium channels, which regulate a wide range of cellular activities. Potassium channels work to quickly and selectively conduct potassium ions down their electrochemical gradient. In many cells, these channels function to either set or reset the resting potential. The delayed counterflow of potassium ions in excitable cells, like neurons, shapes the action potential. Failure of potassium channels can lead to potentially fatal arrhythmias by helping to control the duration of the action potential in cardiac muscle. Maintaining vascular tone may also involve potassium channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73644 | HsTX1 | 201948-00-7 | HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. |
|
V73597 | Iberiotoxin | 129203-60-7 | Iberiotoxin is a toxin extracted from the venom of Buthus tamulus. |
|
V80344 | Iberiotoxin TFA | Iberiotoxin (TFA) is a selective, high-conductivity Ca2+-activated K+ channel inhibitor (antagonist) with a Kd of approximately 1 nM. | |
|
V30913 | ICA 110381 | 325457-99-6 | ICA 110381 (Compound 16) is a potent KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. |
|
V73594 | ICA-105665 (PF-04895162) | 2694728-63-5 | ICA-105665 (PF-04895162) is a potent orally bioactive neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channel agonist. |
|
V18321 | ICA-27243 | 325457-89-4 | ICA-27243 is a selective and orally bioactive KCNQ2/Q3 potassium channel opener with EC50 of 0.38 μM. |
|
V3239 | ICA069673 | 582323-16-8 | ICA-069673 (ICA73) is a selective KCNQ2/Q3potassium channel activator with IC50of 0.69 μM. |
|
V73641 | Icariside E4 | 126253-42-7 | Icariside E4 is an anti-pain agent extracted from Tabebuia roseo-alba. |
|
V11884 | Indapamide | 26807-65-8 | Indapamide (Natrilix,Noranat, Fludex, Tertensif) is a potent thiazide-like diureticused in the treatment of hypertension, as well as decompensated cardiac failure. |
|
V50912 | Isopimaric acid | 5835-26-7 | Isopimaric acid is a potent opener of large conductance calcium activated K+ (BK) channels. |
|
V80445 | Jingzhaotoxin-X (JZTX-X) | Jingzhaotoxin-X (JZTX-X) is a selective Kv4.2 and Kv4.3 potassium channel inhibitor. | |
|
V80446 | Jingzhaotoxin-XII (JzTx-XII) | Jingzhaotoxin-XII (JzTx-XII) is a specific Kv4.1 channel inhibitor (antagonist) with IC50 of 0.363 μM. | |
|
V22954 | JNJ303 | 878489-28-2 | JNJ303 is a potent and specific inhibitor of heteromeric Kv7.1/KCNE1 channel complexes in a concentration- and time-dependent manner. |
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V73645 | Kaliotoxin (1-37) | 150769-72-5 | Kaliotoxin (1-37) is a toxin from the scorpion Artdroctonus mauretanicus. |
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V73652 | KCa2 channel modulator 2 | 2764618-34-8 | KCa2 channel modulator 1 (compound 2q) is a specific positive modulator of KCa2 channel subtypes. |
|
V1682 | KPT-185 | 1333151-73-7 | This product has been discontinued. |
|
V80519 | KTX-Sp2 | KTX-Sp2 is a potassium channel toxin. | |
|
V80521 | KV1.3-IN-1 | KV1.3-IN-1 (Compound trans-18) is a KV1.3 channel inhibitor (IC50= 230 nM and 26.12 nM in Ltk? cells and PHA-activated T lymphocytes, respectively). | |
|
V73616 | Kv3 modulator 5 | 1380696-68-3 | Kv3 modulator 5 (Example 5) is a Kv3 channel modulator. |
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V73656 | Lei-Dab7 | 1061556-49-7 | Lei-Dab7 is a potent and specific SK2 (KCa2.2) channel blocker with a Kd of 3.8 nM. |
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