The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V32977 | GV-58 | 1402821-41-3 | GV-58 is a pupin analog that acts as a novel, potent and selective agonist of N- and P/Q-type Ca2+ channels with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel. |
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V1697 | Hydrocortisone (Cortisol) | 50-23-7 | Hydrocortisone (Cortisol; H-Cort) is a steroid hormone and/or endogenous glucocorticoid produced by the adrenal gland for the treatment of adrenocortical insufficiency. |
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V2429 | IGS-1.76 | 313480-47-6 | IGS-1.76 potently inhibits the human NCS-1/Ric8a complex. |
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V8190 | Imperatorin | 482-44-0 | Imperatorin is a potent NO synthesis inhibitor (antagonist) with IC50 of 9.2 μmol and a BChE inhibitor (antagonist) with IC50 of 31.4 μmol. |
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V1694 | IOWH032 | 1191252-49-9 | IOWH-032 (IOWH032; IOWH 032) is a potent and synthetic CFTR (Cystic fibrosis transmembrane conductance regulator) inhibitor with antifibrotic activity. |
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V1885 | Isoxazole 9 (ISX-9) | 832115-62-5 | Isoxazole 9 (also known as Isx-9) is a synthetic promotor/inducer of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). |
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V1429 | Isradipine (PN 200-110) | 75695-93-1 | Isradipine (formerly known as PN-200-110, PN-205-033, PN-205-034; DynaCirc, Prescal, Lomir)is a potent and selective L-type voltage-gated CBB/calcium channel blocker of the dihydropyridine class with antihypertensive effects. |
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V1689 | Ivacaftor (VX-770) | 873054-44-5 | Ivacaftor (formerly also known as VX-770; trade name:KALYDECO andSymdeko) is a potent and orally bioactive potentiator of CFTR (cystic fibrosis transmembrane conductance regulator) with potential anti-fibrotic activity. |
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V1199 | Lacidipine (GX-1048, GR-43659X, SN-305, Lacipil, Motens) | 103890-78-4 | Lacidipine (GX-1048, GR-43659X, SN-305; GX1048, GR43659X, SN305; Caldine, Lacimen, Lacipil, Midotens, Motens)is a potent and 3rd-generation L-type CCB (calcium channel blocker) that has been approved in 1990s for treating high blood pressure. |
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V23311 | Lercanidipine HCl (REC 15-237, Lercadip, Lerdip, Zanidip) | 132866-11-6 | Lercanidipine HCl (REC-15-237,Lercadip, Lerdip, Zanidip)is a 3rd generation and lipophilic CCB (calcium channel blocker) of the dihydropyridine class and a medicationusedtotreathighbloodpressure, withlong lasting antihypertensive action and reno-protective effect. |
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V32690 | Levamlodipine besylate | 150566-71-5 | Levamlodipine besylate,the besylate salt of Levamlodipine which is the S-isomer and impurity of Amlodipine(Amlodis; Amlor, Coroval; Lipinox; Norvasc; Amvaz),is an anti-hypertensive agent of the dihydropyridine (DHP) class and can be used for lowering blood pressure. |
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V1700 | Loteprednol etabonate | 82034-46-6 | Loteprednol etabonate (Lotemax; Alrex; HGP-1; Loterox; Locort;P-5604; HGP1; Lenoxin, CDDD-5604), the esther form of Loteprednol, is a potent glucocorticoid receptor agonist approved as a medication used in treatment of inflammation of the eye due to allergies. |
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V1692 | Lubiprostone (SPI-0211; RU0211) | 136790-76-6 | Lubiprostone (formerly SPI-0211;RU-0211; RU0211; Spi0211; trade name Amitiza), a bicyclic fatty acid derived from prostaglandin E1 that acts as potent activator of ClC-2 chloride channels, is an FDA-approved drug to manage idiopathic chronic constipation. |
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V1690 | Lumacaftor (VX-809; VRT 826809) | 936727-05-8 | Lumacaftor(formerly VX809; VRT-826809; VRT826809; VX-809; Orkambi) is a potent and orally bioavailable CFTR (cystic fibrosis transmembrane conductance regulator) corrector with antifibrotic effects. |
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V1712 | Meprednisone (Betapar) | 1247-42-3 | Meprednisone (formerly NSC-527579; SCH-4358; NSC63278; SCH4358;Betapar; Medrysone)is a glucocorticoid and a methylated derivative of prednisone acting as a glucocorticoid receptor agonist and has been approved for use to treat allergic and inflammatory of the eye. |
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V1703 | Methylprednisolone | 83-43-2 | Methylprednisolone (formerly NSC-19987; U-7532;NSC19987)is a synthetic glucocorticoid receptor agonist approved for use in the treatment of arthritis and bronchial inflammation or acute bronchitis. |
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V3670 | Mibefradil (Ro405967) | 116644-53-2 | Mibefradil (formerly Ro-405967; Ro 40-5967; trade name: Posicor), an approved drug that can be used for the treatment of hypertension and chronic angina pectoris, is acalcium channelblocker/CCB with moderate selectivity for T-type Ca2+channels displayingIC50s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively. |
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V25561 | Mirogabalin (DS5565) | 1138245-13-2 | Mirogabalin (DS-5565) is a potent,selective and orally bioavailableα2δ-1 ligand under development for treating pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. |
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V25560 | Mirogabalin besylate (DS 5565 besylate) | 1138245-21-2 | Mirogabalin besylate (DS-5565) is a potent,selective and orally bioavailableα2δ-1 ligand under development for treating pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. |
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V4008 | ML218 | 1346233-68-8 | ML218 (CID-45115620; ML-218; CID45115620) is a novel, potent and selective T-Type Ca(2+) (Ca(v)3.1, Ca(v)3.2, Ca(v)3.3) inhibitor (Ca(v)3.2, IC(50) = 150 nM in Ca(2+) flux; Ca(v)3.2 IC(50) = 310 nM and Ca(v)3.3 IC(50) = 270 nM, respectively in patch clamp electrophysiology) with good DMPK properties, it displayed acceptable in vivo rat PK and excellent brain levels. |
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