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    IOWH032
    IOWH032

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1694
    CAS #: 1191252-49-9Purity ≥98%

    Description: IOWH-032 is a potent and synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. IOWH032 inhibited CFTR activity with IC50 value of 6.87 μM in T84-CFTR cell based assays [1]. IOWH-032 rapidly blocked and potentiated hCFTR activity in a concentration-dependent manner with apparent Kd value of 6.1 nM and 0.64 nM, respectively. However, IOWH-032 did not potentiate and only blocked mCFTR with an apparent Kd value of 42.9 μM.

    References: Future Med Chem. 2011 Aug;3(10):1317-25.

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    Molecular Weight (MW)545.18
    FormulaC22H15Br2N3O4 
    CAS No.1191252-49-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (183.4 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide .

    InChi Key: DSFNLJXHXBIKDS-UHFFFAOYSA-N

    InChi Code: InChI=1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29)

    SMILES Code: O=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3

    Synonyms

    IOWH032; IOWH-032; IOWH 032


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    In Vitro

    In vitro activity: IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM.

    In VivoIn a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.
    Animal modelA cecetomized rat model
    Formulation & DosageDissolved in DMSO; ~5 mg/kg; p.o.
    References

    Future Med Chem. 2011;3(10):1317-25.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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