The ion channel known as the calcium channel exhibits selective permeability to calcium ions. Although there are ligand-gated calcium channels as well, it is sometimes referred to as a voltage-dependent calcium channel. Even though the concentration of Na+ outside of cells is 70 times higher than that of Ca2+, voltage-gated calcium (CaV) channels catalyze a rapid, highly selective influx of Ca2+ into cells. A side effect of some calcium channel blockers is that they slow your heart rate, which helps to lower blood pressure, treat angina, and regulate irregular heartbeats.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0369 | Verapamil HCl (CP-16533-1) | 152-11-4 | Verapamil (sold under various trade names such as: Calan, Cordilox, Dexverapamil, Falicard, Finoptin, Hydrochloride, Verapamil, Iproveratril, Isoptin, Isoptine, Izoptin, Lekoptin) is a selective and potent L-type calcium channel blockerin the phenylalkylamine class, it is an FDA approved medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia. |
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V10543 | YM-58483(BTP2) | 223499-30-7 | YM-58483, formerly known as BTP 2, is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM). |
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