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Description: Isradipine (also known as Dynacirc; PN 200-110) is a potent and selective L-type voltage-gated calcium channel blocker of the dihydropyridine class. It is commonly prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. More recent research in animal models suggests that isradipine may have potential uses for treating Parkinson's disease.
References: Gen Pharmacol. 1998 Jan;30(1):85-7; Neurobiol Dis. 2009 May;34(2):230-44.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Isradipine produces inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen strain, at micromolar concentrations. Isradipine is found to be the most potent derivative in both, in growth cultures (I50 = 20.8 mM) and in vivo oxygen uptake (I50 = 31.1 mM).
Gen Pharmacol. 1998 Jan;30(1):85-7; Neurobiol Dis. 2009 May;34(2):230-44.
Purity ≥98%
COA
MSDS
NMR