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Isradipine (PN 200-110)

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InvivoChem Cat #: V1429

CAS #: 75695-93-1Purity ≥98%

Description: Isradipine (formerly known as PN-200-110, PN-205-033, PN-205-034; DynaCirc, Prescal, Lomir) is a potent and selective L-type voltage-gated CBB/calcium channel blocker of the dihydropyridine class with antihypertensive effects. It is commonly prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. More recent research in animal models suggests that isradipine may have potential uses for treating Parkinson's disease.

References: Gen Pharmacol. 1998 Jan;30(1):85-7; Neurobiol Dis. 2009 May;34(2):230-44.

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Molecular Weight (MW)	371.39
Formula	C19H21N3O5
CAS No.	75695-93-1
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (199.3 mM)
	Water: <1 mg/mL
	Ethanol: 74 mg/mL (199.3 mM)
Solubility (In vivo)	2% DMSO+Corn oil: 10mg/mL
Synonyms	PN 200-110; DynaCirc, Prescal, Lomir, PN-200-110, PN-205-033, PN-205-034

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In Vitro	In vitro activity: Isradipine produces inhibition of both growth cultures and oxygen consumption on epimastigotes of Trypanosoma cruzi Tulahuen strain, at micromolar concentrations. Isradipine is found to be the most potent derivative in both, in growth cultures (I50 = 20.8 mM) and in vivo oxygen uptake (I50 = 31.1 mM).
In Vivo	Isradipine reduces hypoxia-induced activation of calcium dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A(2) and cyclooxygenases (COX-2) along with concomitant decrease in free radical generation and cytochrome c release. Isradipine prevents hypobaric hypoxia along with augmented neurodegeneration and memory impairment induced increased expression of calpain and caspase 3. Isradipine (at the dose of 1 mg/kg three times a day) reduces ethanol intake by over 70% in ethanol-preferring rats, the reduction in ethanol intake is compensated by a proportional increase in water consumption and the inhibitory effect persisted throughout the 5 days of treatment. Isradipine significantly reduces the arterial wall collagen contents in both strains, with marked increases in the elastin content in the carotid but not in the aortic wall in spontaneously hypertensive rats. Isradipine suppresses the reinforcing properties of morphine and cocaine and may be an effective pharmacotherapy for treatment of cocaine and heroin abuse in mice.
Animal model	Mice
Formulation & Dosage	1 mg/kg
References	Gen Pharmacol. 1998 Jan;30(1):85-7; Neurobiol Dis. 2009 May;34(2):230-44.

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