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    Loteprednol etabonate
    Loteprednol etabonate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1700
    CAS #: 82034-46-6Purity ≥98%

    Description: Loteprednol etabonate, the esther of Loteprednol, is a potent glucocorticoid receptor agonist, it is used in treatment of inflammation of the eye due to allergies. Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone.

    References: J Steroid Biochem Mol Biol. 1991 Feb;38(2):149-54; Pharmazie. 1999 Jan;54(1):58-61.


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    Molecular Weight (MW)466.95
    FormulaC24H31ClO7 
    CAS No.82034-46-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 93 mg/mL (199.2 mM)
    Water:<1 mg/mL
    Ethanol: 4 mg/mL (8.6 mM)
    Solubility (In vivo)
    SynonymsLoteprednol Etabonate; Lotemax; Alrex; HGP-1; Loterox; Locort;


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    In Vitro

    In vitro activity: Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor.


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    In VivoLoteprednol etabonate administrated directly into the joint effectively blocks the inflammatory response. Loteprednol etabonate prevents the adverse inflammatory effects of antigen action in a rabbit acute experimental model for arthritis. Loteprednol etabonate (LE) (oral) reaches the upper GI tract effectively, but not the colon, due to absorption and/or decomposition in rats. Loteprednol etabonate (LE) shows a rapid, dose-dependent elimination with a total blood clearance (CLtotal) of higher than 60 ml/min/kg in rats. Loteprednol etabonate absorbes systemically, after topical administration, can be rapidly transformed to the inactive metabolites, and eliminates from the body mainly through the bile and urine. 
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    References

    J Steroid Biochem Mol Biol. 1991 Feb;38(2):149-54; Pharmazie. 1999 Jan;54(1):58-61.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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