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    Hydrocortisone (Cortisol)
    Hydrocortisone (Cortisol)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1697
    CAS #: 50-23-7Purity ≥98%

    Description: Hydrocortisone (Cortisol; H-Cort) is a steroid hormone and/or endogenous glucocorticoid produced by the adrenal gland for the treatment of adrenocortical insufficiency. Hydrocortisone is a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone initially binds to the cytoplasmic glucocorticoid receptor then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. 

    References: J Physiol. 2008 Apr 1;586(7):1937-49; J Allergy Clin Immunol. 2001 Aug;108(2):242-9.

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    Molecular Weight (MW)362.46
    FormulaC21H30O5
    CAS No.50-23-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 73 mg/mL (201.4 mM)
    Water:<1 mg/mL
    Ethanol:<23 mg/mL (63.5 mM)
    Other info

    Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

    InChi Key: JYGXADMDTFJGBT-VWUMJDOOSA-N

    InChi Code: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

    SMILES Code: C[[email protected]@]12[[email protected]](C(CO)=O)(O)CC[[email protected]@]1([H])[[email protected]]3([H])CCC4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])[[email protected]@H](O)C2)=O

    Synonyms

    Hydrocortisone; Cortisol; H-Cort


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    In Vitro

    In vitro activity: Hydrocortisone prevents endothelial barrier breakdown in response to pro-inflammatory stimuli (TNFalpha administration) in the human brain microvascular endothelial cell line hCMEC/D3, which could be demonstrated to be partly based on maintenance of occludin levels. Hydrocortisone-treated dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibits production of IFN-gamma but induces an increased release of IL-4 and no change in IL-5. Hydrocortisone reduces T-cell proliferation in dendritic cells. Hydrocortisone prevents TNF-alpha induced severe degradation of the glycocalyx, increased coronary resistance, heightened vascular leak and permeability to hydroxyethyl starch and caused mast-cell degranulation in isolated guinea pig hearts. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation in isolated guinea pig hearts. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan, as well as release of histamine from resident mast cells. Hydrocortisone increases the levels of IL-4-induced germ line C epsilon transcripts by twofold and delivers the signal required for transcription of mature C epsilon mRNA. Hydrocortisone induces S mu-S epsilon deletional switch recombination in IL-4-treated B cells, and support a model of sequential isotype switching from IgM to IgE via IgG4. 

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    References

    J Physiol. 2008 Apr 1;586(7):1937-49; J Allergy Clin Immunol. 2001 Aug;108(2):242-9.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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