My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Isoxazole 9 (ISX-9)
    Isoxazole 9 (ISX-9)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1885
    CAS #: 832115-62-5Purity ≥98%

    Description: Isoxazole 9 (also known as Isx-9) is a synthetic promotor/inducer of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isx-9 promotes neurogenesis in vivo, enhancing the proliferation and differentiation of hippocampal subgranular zone (SGZ) neuroblasts, and the dendritic arborization of adult-generated dentate gyrus neurons. Isx-9 also improves hippocampal function, enhancing memory in the Morris water maze. Notably, Isx-9 enhances neurogenesis and memory without detectable increases in cellular or animal activity or vascularization. 

    References: PLoS One. 2015 Sep 25;10(9):e0138724; FASEB J. 2012 Aug;26(8):3148-62.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)234.27 
    FormulaC11H10N2O2S 
    CAS No.832115-62-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 46 mg/mL (196.4 mM) 
    Water: <1 mg/mL
    Ethanol: 13 mg/mL (55.5 mM) 
    Solubility (In vivo)5% DMSO+55% PEG 300+ddH2O: 10mg/mL  
    SynonymsISX-9; ISX 9; ISX9; Isoxazole 9; Isoxazole-9


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.


    Cell Assay: Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.

    In VivoIn mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.  
    Animal modelTransgenic Nkx2.5-luciferase reporter mice 
    Formulation & DosageFormulated in 30 % (2-hydroxypropyl)-β-cyclodextrin; 20 mg/kg; i.p. injection
    References

    PLoS One. 2015 Sep 25;10(9):e0138724; FASEB J. 2012 Aug;26(8):3148-62. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Isoxazole 9 (ISX-9)

    Isx-9 increased the number of NSPCs. PLoS One. 2015 Sep 25;10(9):e0138724.
     

    Isoxazole 9 (ISX-9)

    Isx-9 promoted the differentiation of NSPCs. PLoS One. 2015 Sep 25;10(9):e0138724.
     

    Isoxazole 9 (ISX-9)

    Isx-9 induced cell damage in OPCs. PLoS One. 2015 Sep 25;10(9):e0138724.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?