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    Medetomidine HCl (MPV-785)
    Medetomidine HCl (MPV-785)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1141
    CAS #: 86347-15-1 Purity ≥98%

    Description: Medetomidine HCl (MPV-785; MPV 785; MPV785; Precedex. Domitor; Selektope) is a selective and synthetic α2-adrenoceptor agonist with analgesic and anesthetic effects. It activates α2-adrenoceptor with a Ki of 1.08 nM, and exhibits 1620-fold selectivity over α1-adrenoceptor. Medetomidine has been approved for use as both a surgical anesthetic and analgesic. It is an alpha-2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. Medetomidine is a racemic mixture of two stereoisomers; dexmedetomidine is the isomer with more useful effects, and is now marketed as Dexdomitor.

    References: Eur J Pharmacol. 1988 May 20;150(1-2):9-14; J Auton Pharmacol. 1986 Dec;6(4):275-84.

    Related CAS #: 86347-15-1 (HCl)   86347-14-0 (free base)

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    Molecular Weight (MW)236.74 
    FormulaC13H16N2.HCl 
    CAS No.86347-15-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 12 mg/mL (50.7 mM) 
    Water: 47 mg/mL (198.5 mM)
    Ethanol: 47 mg/mL (198.5 mM)
    Solubility (In vivo)Saline: 30 mg/mL  
    SynonymsMPV-785; Medetomidine HCl; Medetomidine hydrochloride; MPV 785; MPV785; Precedex. Domitor. Selektope.


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    In Vitro

    In vitro activity: Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors.

    In VivoIn anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover. 
    Animal modelRat
    Formulation & DosageDissolved in saline; 1-100 μg/kg; i.v. injection
    References

    Eur J Pharmacol. 1988 May 20;150(1-2):9-14; J Auton Pharmacol. 1986 Dec;6(4):275-84. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Medetomidine HCl

    Effect of medetomidine on electrically evoked tritium overflow from MPLM segments preincubated with [3H]-choline. Br J Pharmacol. 2002 Feb; 135(3): 697–704.
     

    Medetomidine HCl

    Effect of medetomidine on electrically evoked tritium overflow from MPLM segments preincubated with [3H]-noradrenaline. Br J Pharmacol. 2002 Feb; 135(3): 697–704.
     

    Medetomidine HCl

    Effect of medetomidine on gastrointestinal transit in conscious wild type and α2A-knockout mice. Br J Pharmacol. 2002 Feb; 


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