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    Maprotiline HCl
    Maprotiline HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1116
    CAS #: 10347-81-6Purity ≥98%

    Description: Maprotiline HCl (Psymion; Ludiomil), the hydrochloride salt of Maprotiline which is a tetracyclic antidepressant, is a selective noradrenalin reuptake inhibitor that has been approved for the treatment of depression. 

    References: Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8; Cancer Lett. 2009 Apr 8;276(1):14-20.

    Related CAS #: 10347-81-6 (HCl)   10262-69-8 (free)  

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    Molecular Weight (MW)313.86 
    FormulaC20H23N.HCl 
    CAS No.10347-81-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 63 mg/mL (200.7 mM) 
    Water: <1 mg/mL
    Ethanol: 24 mg/mL (76.5 mM) 
    Other info

    Chemical Name: 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride

    InChi Key: NZDMFGKECODQRY-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H

    SMILES Code: CNCCCC1(CC2)C3=CC=CC=C3C2C4=C1C=CC=C4.Cl

    Synonyms

    Psymion; Ludiomil; Maprotilline HCl; Maprotiline Hydrochlorine; Maprotiline Hcl


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    In Vitro

    In vitro activity: Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum.

    In VivoMaprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training.
    Animal modelMice
    Formulation & DosageNA
    References

    Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8; Cancer Lett. 2009 Apr 8;276(1):14-20. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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