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Description: Maprotiline HCl (Psymion; Ludiomil), the hydrochloride salt of Maprotiline which is a tetracyclic antidepressant, is a selective noradrenalin reuptake inhibitor that has been approved for the treatment of depression.
References: Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8; Cancer Lett. 2009 Apr 8;276(1):14-20.
Related CAS #: 10347-81-6 (HCl) 10262-69-8 (free)
Chemical Name: 9-(γ-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene hydrochloride
InChi Key: NZDMFGKECODQRY-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H
SMILES Code: CNCCCC1(CC2)C3=CC=CC=C3C2C4=C1C=CC=C4.Cl
Psymion; Ludiomil; Maprotilline HCl; Maprotiline Hydrochlorine; Maprotiline Hcl
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum.
Eur J Pharmacol. 2006 Feb 15;531(1-3):1-8; Cancer Lett. 2009 Apr 8;276(1):14-20.
Purity ≥98%
COA
MSDS