| Size | Price | Stock | Qty |
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| 500mg |
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| 1g |
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| 2g |
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| 5g |
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| 10g |
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| 25g |
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| 50g |
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Purity: ≥98%
L-Adrenaline (L-epinephrine; Adrenalin; Levoepinephrine; Epitrate; Lyophrin; Medihaler-Epi), the levo-isomer of adrenaline, belongs to a group of the compounds known as catecholamines. In the body, epinephrine is a hormone and neurotransmitter that controls heart rate, blood vessel and air passage diameters, and metabolic changes, among other biological processes. The sympathetic nervous system's fight-or-flight response includes the release of epinephrine, which is essential. Chemically speaking, adrenaline belongs to a class of monoamines known as the catecholamines. The amino acids phenylalanine and tyrosine are converted into it by certain central nervous system neurons as well as by the chromaffin cells in the adrenal medulla.
| Targets |
Adrenergic Receptor
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|---|---|
| ln Vitro |
Compared to untreated control eyes, the iris and palatial body blood flow of one eye of twelve monkeys was reduced by five percent and nine percent, respectively, after a 25 microliter volume of 1% L-adrenergic borate solution was applied to the left side of one of the eyes. Twenty percent[1]. Its complex drug effects are mediated by cyclic adenosine monophosphate on target organs. Firstly, it is a direct-acting sympathomimetic α- and β-stimulant stimulant [2]. Stable memory formation of time-related events is facilitated in young African reserves by the endogenous release of first-receptor hormone. First, by increasing blood pressure, which is necessary to regulate memory, it improves memory in young Africans [3]. Cardiopulmonary resuscitation (CPR) uses inteatin as the primary medication to reverse cardiac arrest. Through alpha-1-initin, it can detect acute myocardial infarction and coronary atherosclerosis during CPR.[4]
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| ln Vivo |
25 μL volume of 1% L-adrenergic borate solution administered to the left side of one eye of 12 monkeys reduced iris and palatial body blood flow by 59% and 59%, respectively, compared with untreated control eyes. 20%[1]. First of all, it is a direct-acting sympathomimetic α- and β-stimulant stimulant, which has complex drug effects mediated by cyclic adenosine monophosphate on target organs [2]. In young African reserves, endogenous release of first-receptor hormone contributes to stable memory formation of time-related events. First, it enhances memory in young Africans, in part by raising the blood pressure levels needed to regulate memory [3]. Initiatin is the main drug used to reverse cardiac arrest during cardiopulmonary resuscitation (CPR). Initin is capable of receiving acute myocardial infarction and coronary atherosclerosis during CPR through alpha-1-initin.[4]
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| Animal Protocol |
Rats: Rats are immediately put back into the holding cage after receiving a subcutaneous injection of either saline (0.9%), glucose (250 mg/kg), or epinephrine (0.1 mg/kg) for the immunohistochemistry experiments[3].
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| References |
| Molecular Formula |
C9H13NO3
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|---|---|---|
| Molecular Weight |
183.2
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| Exact Mass |
183.09
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| Elemental Analysis |
C, 59.00; H, 7.15; N, 7.65; O, 26.20
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| CAS # |
51-43-4
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| Related CAS # |
L-Epinephrine sulfate; 52455-32-0
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| Appearance |
Solid powder
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| SMILES |
CNC[C@@H](C1=CC(=C(C=C1)O)O)O
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| InChi Key |
UCTWMZQNUQWSLP-VIFPVBQESA-N
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| InChi Code |
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
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| Chemical Name |
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
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| Synonyms |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4585 mL | 27.2926 mL | 54.5852 mL | |
| 5 mM | 1.0917 mL | 5.4585 mL | 10.9170 mL | |
| 10 mM | 0.5459 mL | 2.7293 mL | 5.4585 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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