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    Isoprenaline HCl (Isoproterenol HCl)
    Isoprenaline HCl (Isoproterenol HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1119
    CAS #: 51-30-9Purity ≥98%

    Description: Isoprenaline HCL (NCIc55630; NCI c55630; Isoproterenol), the hydrochloride salt of Isoprenaline, is a non-selective beta-adrenergic receptor agonist that has been used for the treatment of bradycardia and heart block. 

    References: Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7; Biochem J. 1992 Nov 15;288 ( Pt 1):325-30.

    Related CAS #: 51-31-0 (free base)   5984-95-2 (HCl)   299-95-6 (Isoproterenol sulfate dihydrate)

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    Molecular Weight (MW)247.72 
    FormulaC11H17NO3.HCl 
    CAS No.51-30-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 50 mg/mL (201.8 mM)
    Water: 50 mg/mL (201.8 mM)
    Ethanol: <1 mg/mL
    Solubility (In vivo)

    Chemical Name: 4-[(1R)-1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride

    InChi Key: IROWCYIEJAOFOW-MERQFXBCSA-N

    InChi Code: InChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H/t11-;/m0./s1

    SMILES Code: OC1=CC=C([[email protected]@H](O)CNC(C)C)C=C1O.[H]Cl

    SynonymsNCI-c55630; Isoprenaline hydrochloride; NCIc55630; NCI c55630; Isoproterenol


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    In Vitro

    In vitro activity: Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells. Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity. Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO). Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged. Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells.


    Cell Assay: In human umbilical vein endothelial cells (HUVECs), isoprenaline (100 nM) significantly increased the expression of connexins Cx43 and also increased Cx40 and Cx37. Also, isoprenaline increased the number of coupling cells. Isoprenaline enhanced the formation of branches and complex tube networks.

    In VivoIn the isolated field stimulated rat vas deferens, isoprenaline inhibited contractions with EC50 value of 45.6 nM. In tissues in which β 2-adrenoreceptors were maximally blocked by timolol, isoprenaline inhibited contractility with EC50 value of 1.5 μM. In CFW mice, IPR caused the maximal proliferative response of bone marrow cells and increased erythropoietic activity. These results suggested that isoprenaline activated beta-adrenergic receptor, which then increased the proliferative and differentiation activities of hemopoietic stem cells. 
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    References

    Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7; Biochem J. 1992 Nov 15;288 ( Pt 1):325-30. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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