The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71341 | 2-MPMDQ | 149847-77-8 | 2-MPMDQ is a potent antagonist of α1-adrenoceptor (Ki=0.37 nM), with a Ki of α2-adrenoceptor of 1740 nM. |
|
V71300 | 4-Hydroxypropranolol-d7 ((±)-4-Hydroxypropranolol-d7) | 1219908-86-7 | 4-Hydroxypropranolol-d7 is the deuterated form of 4-Hydroxypropranolol HCl. |
|
V1109 | Acebutolol HCl | 34381-68-5 | Acebutolol HCl (Neptal; Prent; Sectral; Dl-Acebutolol), the hydrochloride salt of acebutolol, is a potent antagonist of β-adrenergic receptor with antihypertensive effects. |
|
V77293 | ACTH (1-14) (TFA) (Adrenocorticotropic Hormone Fragment 1-14 TFA) | ACTH (1-14) (TFA) is a bioactive peptide fragment of adrenocorticotropic hormone, which promotes the release of cortisol. | |
|
V71270 | ADRA1D receptor antagonist 1 free base | 1191908-24-3 | ADRA1D receptor antagonist 1 (free base) (Compound (R)-9s) is an orally bioavailable, potent and specific human α1D adrenergic receptor (α1D-AR) antagonist (Ki=1.6 nM). |
|
V1148 | Adrenalone HCl | 62-13-5 | Adrenalone HCl (Adrenalonium chloratum, Adrenone, Epinephrine ketone, Kephrine, Stryphnonasal), the hydrochloride salt of adrenalone, is a potent adrenergic agonist used as a topical vasoconstrictor and hemostatic. |
|
V77825 | AdTx1 | AdTx1 is a selective α1A-adrenoceptor antagonist (Ki= 0.35 nM). | |
|
V71329 | Akuammigine | 642-17-1 | Akuammigine is an alkaloid found in Uncaria uncariae. |
|
V71199 | AL-34662 | 210580-75-9 | AL-34662 is a selective 5-HT2A receptor agonist (IC50= 0.77 nM and 1.5 nM for rat and human 5-HT2 receptors, respectively). |
|
V1099 | Alfuzosin HCl (SL 77499-10 HCl) | 81403-68-1 | Alfuzosin HCl (Alfetim; alfusozine; SL-77499; alphuzosine; Benestan; Urion; UroXatral; Xatral), the hydrochloride salt of alfuzosin, is an approved/marketed drug which acts as an alpha1 adrenergic receptor antagonist. |
|
V71316 | Alfuzosin-d7 (SL 77499-d7) | 1133386-93-2 | Alfuzosin-d7 is the deuterated form of Alfuzosin. |
|
V71304 | Alfuzosin-d7 hydrochloride (SL 77499-10-d7) | 1276197-14-8 | Alfuzosin-d7 ( HCl) is the deuterated form of Alfuzosin HCl. |
|
V4656 | Amezinium Metilsulfate | 30578-37-1 | Amezinium metilsulfate stimulates alpha and beta-1 receptors and inhibits norepinephrine and tyramine absorption. |
|
V71340 | Amidephrine ((±)-Amidephrine) | 37571-84-9 | Amidephrine is a selective alpha 1-adrenoceptor agonist. |
|
V71292 | Anisodamine hydrochloride (6-Hydroxyhyoscyamine hydrochloride) | 131674-05-0 | Anisodamine HCl is an anticholinergic and α1 adrenergic receptor antagonist. |
|
V4360 | ARC-239 dihydrochloride | 55974-42-0 | ARC 239 diHCl is a selective α2B/2C adrenergic receptor blocker (antagonist) (pKds for α2A, α2B, and α2C receptors are 5.95, 7.41, and 7.56, respectively). |
|
V3727 | Arformoterol | 67346-49-0 | Formoterol (also named as Arformoterol) is a long-acting β2 agonist (LABA) used in the treatment of asthma and COPD (chronic obstructive pulmonary disease). |
|
V3729 | Arformoterol Maleate | 1254575-18-2 | Formoterol maleate is a long-acting β2 agonist (LABA) used in the treatment of asthma and COPD (chronic obstructive pulmonary disease). |
|
V3726 | Arformoterol tartrate | 200815-49-2 | Formoterol (also named as Arformoterol) is a long-acting β2 agonist (LABA) used in the treatment of asthma and COPD (chronic obstructive pulmonary disease). |
|
V40359 | Arotinolol (Almarl) | 68377-92-4 | Arotinolol (Almarl) is a medication acting as a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. |
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