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    Alfuzosin HCl (SL 77499-10 HCl)
    Alfuzosin HCl (SL 77499-10 HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1099
    CAS #: 81403-68-1Purity ≥98%

    Description: Alfuzosin HCl (Alfetim; alfusozine; SL-77499; alphuzosine; Benestan; Urion; UroXatral; Xatral), the hydrochloride salt of alfuzosin, is an approved/marketed drug which acts as an alpha1 adrenergic receptor antagonist. It has been approved for use in the treatment of benign prostatic hyperplasia (BPH). 

    References: J Pharmacol Exp Ther. 2008 Feb;324(2):427-33; Eur Urol. 2004 Jan;45(1):110-6.

    Related CAS #: 81403-68-1 (HCl)   81403-80-7(Alfuzosin).  

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    • 香港大学
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    Molecular Weight (MW)425.91
    FormulaC19H27N5O4.HCl
    CAS No.81403-68-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 85 mg/mL (199.6 mM) 
    Water: 85 mg/mL (199.6 mM) 
    Ethanol: 85 mg/mL (199.6 mM) 
    Other info

    Chemical Name: N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide, monohydrochloride

    InChi Key: YTNKWDJILNVLGX-UHFFFAOYSA-N

    InChi Code: InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H

    SMILES Code: O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.[H]Cl

    Synonyms

    SL-77499; Alfetim; alfusozine; alfuzosin; SL 77499; SL77499; alfuzosin hydrochloride; alphuzosine; Benestan; Urion; UroXatral; Xatral


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    In Vitro

    In vitro activity: Alfuzosin significantly increases whole-cell peak sodium (hNa(v)1.5) current, increases the probability of late hNa(v)1.5 single-channel openings, and significantly shortens the slow time constant for recovery from inactivation. Alfuzosin also increases hNa(v)1.5 burst duration and number of openings per burst between 2- and 3-fold. Alfuzosin shows a concentration-dependent relaxing effect on rabbit corpus cavernosum (CC) pre-contracted by 10 mM phenylephrine.

    In VivoAlfuzosin (300 nM) significantly prolongs action potential duration (APD)(60) in rabbit Purkinje fibers and QT in isolated rabbit hearts. Alfuzosin enhances the number and amplitude of erections induced by apomorphine in spontaneous hypertensive rats (SHR). Alfuzosin behaves as an alpha-adrenergic antagonist blocking the contractions induced by exogenous noradrenaline without altering spikes in both portions of the vas deferens. Alfuzosin (0.03-0.3 mg kg-1, i.v.) markedly inhibits pressor responses produced by the alpha 1-selective agonist, Cirazoline but inhibits only slightly responses to the alpha 2-selective agonist, UK 14,304, in the pithed rat. Alfuzosin (1 mg kg-1, i.v.) has minimal effects against responses mediated by stimulation of prejunctional alpha 2-receptors (UK 14,304-induced inhibition of sympathetic tachycardia). Alfuzosin (0.001-1 mg kg-1, i.v.) and Prazosin (0.001-0.3 mg kg-1, i.v.) produces dose-related inhibition of the increases in urethral pressure caused by stimulation of sympathetic hypogastric nerves in the anaesthetized cat.
    Animal modelRats amd cats
    Formulation & Dosage0.001-1 mg kg-1, i.v.
    References

    J Pharmacol Exp Ther. 2008 Feb;324(2):427-33; Eur Urol. 2004 Jan;45(1):110-6


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Alfuzosin HCl
    Alfuzosin delays cardiac repolarization. J Pharmacol Exp Ther. 2008 Feb;324(2):427-33. 
     
    Alfuzosin HCl
    Alfuzosin prolongs QT. J Pharmacol Exp Ther. 2008 Feb;324(2):427-33. 
     
    Alfuzosin HCl
    Alfuzosin increases opening probability of late cardiac sodium channels. J Pharmacol Exp Ther. 2008 Feb;324(2):427-33. 


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