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    Acebutolol HCl
    Acebutolol HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1109
    CAS #: 34381-68-5Purity ≥98%

    Description: Acebutolol HCl (Neptal; Prent; Sectral; Dl-Acebutolol), the hydrochloride salt of acebutolol, is a potent antagonist of β-adrenergic receptor with antihypertensive effects. It has been used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.  

    References: J Lipid Res. 1988 May;29(5):587-601; Biopharm Drug Dispos. 1997 Aug;18(6):543-56.

    Related CAS: 1346604-19-0 (Diacetolol D7)

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    Molecular Weight (MW)372.89 
    FormulaC18H28N2O4.HCl 
    CAS No.34381-68-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 75 mg/mL (201.1 mM) 
    Water: 
    Ethanol: 75 mg/mL (201.1 mM) 
    Solubility (In vivo)Saline: 30 mg/mL  
    SynonymsAcebutolol HCl; Acetobutolol; Neptal; Prent; Sectral; Dl-Acebutolol.


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    In Vitro

    In vitro activity: Acebutolol inhibits NA uptake in rat brain P2 fractions with IC50 of 0.25 mM. Acebutolol produces a concentration-dependent inhibition of 125I-labeled CYP binding to human fat cell membranes and are able to completely displace all specifically bound radioligand. Acebutolol totally inhibits lipolytic activity initiated by 1 μM isoproterenol. Acebutolol is a cardioselective antagonist possessing low lipid solubility. Acebutolol, which does not bind to LDL, shows a stronger inhibiting effect on the intracellular accumulation of cholesterol esters in J774 macrophages than alprenolol and oxprenolol which bind to LDL.

    In VivoAcebutolol following single intravenous administration (10 mg/kg) to rat results in the plasma clearance of 61.9 mL/min/kg, the volume of distribution of 9.6 L/kg, and an elimination half-life of 1.8 hours. Acebutolol following single intravenous administration (50 mg/kg) to rat results in the plasma clearance of 46.5 mL/min/kg, the volume of distribution of 9.5 L/kg, and an elimination half-life of 2.3 hours. Acebutolol (30 mg/kg) decreases cardiac output by 65% and 31% after 1 min and 10 min measurements, respectively, in Sprague-Dawley rats. Acebutolol (30 mg/kg) significantly reduces regional blood flow (RBF) in most organs either after 1 min or 10 min measurements when compare with the baseline values in Sprague-Dawley rats. 
    Animal modelSprague–Dawley rats 
    Formulation & DosageDissolved in saline; 10 mg/kg; i.v. injection
    References

    J Lipid Res. 1988 May;29(5):587-601; Biopharm Drug Dispos. 1997 Aug;18(6):543-56. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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