The catecholamines, in particular norepinephrine and epinephrine, are targets of the G protein-coupled receptor class known as adrenergic receptors. These receptors are found on numerous cells, and when a catecholamine binds to one of these receptors, the sympathetic nervous system is typically stimulated. The fight-or-flight response is controlled by the sympathetic nervous system, which causes the eye pupils to dilate, the body to mobilize energy, and the blood supply to skeletal muscle to be diverted from non-essential organs.There are numerous subtypes of the two main groups of adrenergic receptors, and. The receptor subtypes 1 and 2 exist. There are three subtypes of receptors: 1, 2, and 3. They are all associated with Gs proteins, which are associated with adenylate cyclase. Thus, antagonist binding increases the level of the second messenger cAMP inside of the cell. The cAMP-dependent protein kinase (PKA), one of cAMP's downstream effectors, mediates some intracellular processes after hormone binding.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1097 | Asenapine maleate (Org 5222 maleate) | 85650-56-2 | Asenapine maleate (Org5222; Org-5222; HSDB-8061; HSDB8061; Saphris and Sycrest), an atypical antipsychotic, is a potent and high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors. |
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V71240 | Atenolol-d7 ((RS)-Atenolol-d7) | 1202864-50-3 | Atenolol-d7 is the deuterated form of Atenolol. |
|
V2590 | Atipamezole | 104054-27-5 | Atipamezole (Antisedan, MPV-1248)is a synthetic α2 adrenergic receptor antagonistwith a Ki of 1.6 nM. |
|
V2589 | Atipamezole HCl (MPV-1248) | 104075-48-1 | Atipamezole (Antisedan, MPV-1248)is a synthetic α2 adrenergic receptor antagonist with a Ki of 1.6 nM. |
|
V71263 | Atomoxetine-d3 hydrochloride | 1217776-38-9 | Atomoxetine-d3 HCl is deuterium labelled Atomoxetine HCl. |
|
V71299 | Azepexole dihydrochloride (B-HT 933 dihydrochloride; Oxazoloazepin dihydrochloride) | 36067-72-8 | Azepexole (B-HT 933) di-HCl is a potent and specific α2-adrenergic receptor agonist/activator with pKi of 8.3, 7.6, and 7.5 for α2A-, α2B-, and α2C-adrenoceptor subtypes, respectively. |
|
V1103 | Bambuterol HCl (KWD-2183 HCl) | 81732-46-9 | Bambuterol HCl (Bambec; Oxeol; KWD-2183l; UNII-Y1850G1OVC), the hydrochloride salt of Bambuterol which is a prodrug of terbutaline, is a potent andlong acting beta-adrenoceptor agonist (LABA)that was approved (outside the US) for use in the treatment of asthma. |
|
V71251 | Bambuterol-d9 hydrochloride (Bambuterol-d9; (±)-Bambuterol-d9 hydrochloride; KWD-2183-d9 hydrochloride) | 1794810-59-5 | Bambuterol-d9 ( HCl) is the deuterated form of Bambuterol. |
|
V3626 | Batefenterol | 743461-65-6 | Batefenterol (formerly known as GSK961081 and TD-5959) is a novel, potent and selective muscarinic receptor antagonist and β2-adrenoceptor agonist; it displays high affinity for hM2, hM3 muscarinic and hβ2-adrenoceptor with Ki values of 1.4, 1.3 and 3.7 nM, respectively. |
|
V1149 | Betaxolol (SL75212) | 63659-18-7 | Betaxolol (Betoptima; Kerlone; Betoptic; Kerlon; SL-75212 HCl; ALO-140102) is a β1 adrenergic receptor antagonist/blocker with antihypertensive effects. |
|
V1106 | Betaxolol HCl (SL75212) | 63659-19-8 | Betaxolol HCl (Betoptima; Kerlone; Betoptic; Kerlon; SL-75212; ALO-1401-02; ALO140102), the hydrochloride salt of Betaxolol, is a potent beta-1/β1 adrenergic receptor antagonist with antihypertensive effects. |
|
V71328 | Betaxolol-d5 (Betaxolol d5) | 1189957-99-0 | Betaxolol-d5 is the deuterium labelled form of Betaxolol. |
|
V71302 | Betaxolol-d7 hydrochloride (SL75212-d7) | 1219802-92-2 | Betaxolol-d7 ( HCl) is the deuterated form of Betaxolol HCl. |
|
V10379 | Bisoprolol | 66722-44-9 | Bisoprolol (also known as EMD33512)is a potent and selective type β1 adrenergic receptor blocker. |
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V1131 | Bisoprolol fumarate | 104344-23-2 | Bisoprolol fumarate (Zebeta; (+/-)-Bisoprolol hemifumarate; Bisobloc; EMD 33512; EMD33512), the fumarate salt of bisoprolol, is a potent and selective β1 adrenergic receptor antagonist/blocker with potentialantihypertensiveand cardioprotective activities. |
|
V79990 | Bisoprolol-d7 hemifumarate (Bisoprolol d7 (hemifumarate)) | Bisoprolol-d7 (hemifumarate) is the deuterium labelled form of Bisoprolol hemifumarate. | |
|
V70038 | BMY 14802 | 105565-56-8 | BMY 14802 is an antagonist of sigma-1 receptor (σ1R) and an agonist of serotonin 1A receptor (5-HT 1A Receptor) and adrenergic receptor alpha-1 (α-1 adrenergic receptor). |
|
V3485 | Brimonidine (UK 14304; AGN190342) | 59803-98-4 | Brimonidine (UK 14304 and AGN190342) is a highly potent and selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension. |
|
V1105 | Brimonidine Tartrate (UK 14304; AGN190342) | 70359-46-5 | Brimonidine Tartrate (AGN-190342; UK14304; UK-14304; Alphagan), the tartrate salt of Brimonidine, is a highly potent and selective α-adrenergic receptor agonist with anti-hypertensive effects. |
|
V71295 | Brimonidine-d4 (brimonidine d4) | 1184971-51-4 | Brimonidine-d4 is the deuterium labelled form of Brimonidine. |
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