My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Lorcaserin HCl
    Lorcaserin HCl

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1032
    CAS #: 846589-98-8 Purity ≥98%

    Description: Lorcaserin HCl (Belviq Xr; APD-356; APD356; Lorqess), the hydrochloride salt of Lorcaserin which is a marketed weight-loss drug, is a potent and selective full agonist of human 5-HT2C (serotonin) receptor with Ki of 15 nM. It reduces appetite by activating 5-HT2C receptor the hypothalamus, which is known to control appetite.

    References: J Pharmacol Exp Ther. 2008 May;325(2):577-87; J Pharmacol Exp Ther. 2011 Sep;338(3):890-6. 

    Related CAS#: 616202-92-7 (free base); 856681-05-5 (HCl hydrate); 1361572-46-4 (Lorcaserin sulfamate)

    Customer Validation
    Top Publications Citing Invivochem Products
    • Citation of InvivoChem Vorinostat (V0255) by Nature 2021, 597(7874):119-125
    • Citation of InvivoChem Larotrectinib (V2599) by Cell. 2020 Nov 25;183(5):1202-1218.e25
    • Citation of InvivoChem Eprenetapopt (APR-246) by Science Adv 2022: 8, eabm9427.
    • Citation of InvivoChem 5-azacytidine (V0404) by Nature 2021, DOI: 10.1038/s41586-021-03850-3
    • Citation of InvivoChem Larotrectinib (V2599) by Cell 2020, doi: 10.1016/j.cell.2020.10.016.
    • Citation of InvivoChem Eprenetapopt (APR-246) by Science Adv 2022, doi: 10.1126/sciadv.abm9427.
    • Citation of InvivoChem Vorinostat/SAHA (V0255) by Nature 2021, DOI: 10.1038/s41586-021-03850-3.
    • Citation of InvivoChem Vitrakvi by Cell 2020, PMID: 33142117 PMCID: PMC8100789
    • Citation of InvivoChem APR-246 by Science Adv 2022, PMID: 36103522.
    • Citation of InvivoChem 5-azacytidine (V0404) by Nature 2021, DOI: 10.1038/s41586-021-03850-3.
    • Citation of InvivoChem LOXO-101 by Cell 2020, PMID: 33142117 PMCID: PMC8100789
    • Citation of InvivoChem Eprenetapopt by Science Adv 2022, PMID: 36103522.
    • Citation of InvivoChem Vorinostat/SAHA (V0255) by Nature 2021, PMID: 34433969
    • Citation of InvivoChem  ARRY-470 by Cell 2020, PMID: 33142117 PMCID: PMC8100789
    • Citation of InvivoChem 5-azacytidine (V0404) by Nature 2021, PMID: 34433969
    • Citation of InvivoChem BMH-21 (V1435) by Cell Stem Cell 2020, 26(6): 845-861.e12.
    • Citation of InvivoChem Eprenetapopt (APR-246) by Science Adv 2022, doi: 10.1126/sciadv.abm9427.
    • Citation of InvivoChem 5-azacytidine (V0404) by Nature 2021, DOI: 10.1038/s41586-021-03850-3.
    • Citation of InvivoChem V33339 Lys-SMCC-DM1 by PNAS Nexus 2022, pgac063, https://academic.oup.com/pna
    • Citation of InvivoChem 5-azacytidine by Nature 2021, PMID: 34433969
    • Citation of InvivoChem Ruxolitinib/Filgotinib/BMS-911543/Decernotinib by J Allergy Clin Immunol 2020
    • Citation of InvivoChem LGK974 /WNT974 (V1353) by  Cancer Cell 2021 Apr 12;39(4):529-547.e7.
    • Citation of InvivoChem V1386 Napabucasin (BBI-608) by J Exp Clin Cancer Res 2021 Oct 13;40(1):319.
    • Citation of InvivoChem 5-azacytidine (V0404) by Nature 2021, DOI: 10.1038/s41586-021-03850-3.
    • Citation of InvivoChem Epacadostat/INCB024360 (V0942) by Cancer Discov 2022: 12(4):1106-1127.
    • Citation of InvivoChem S63845 (V2797) by Cell Death and Disease 2020, 11:316.
    • Citation of InvivoChem BMS-582949 (V2668) by Cells 2020, 9(6):1472.
    • Citation of InvivoChem Apiin (V4467) by J Med Chem 2020, 63(15):8338-8358.
    • Citation of InvivoChem V0001 venetoclax by WO2021231323A1
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)232.15
    FormulaC11H14ClN.HCl 
    CAS No.846589-98-8 (HCl);
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 46 mg/mL (198.1 mM) 
    Water: 46 mg/mL (198.1 mM) 
    Ethanol: 46 mg/mL (198.1 mM) 
    SMILESC[[email protected]]1CNCCC2=CC=C(Cl)C=C12.[H]Cl
    SynonymsAPD 356; Lorcaserin hydrochloride; Belviq Xr; Lorcaserin HCl; APD-356; APD356; Lorqess. 


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Lorcaserin exhibits higher affinity for human 5-HT2C than to 5-HT 5-HT2A (7.5-fold selective, Ki=112 nM) and 5-HT2B (11.6-fold selective, Ki=174 nM). Lorcaserin possesses agonist activity at all three human 5-HT2 receptors. Lorcaserin is 18-fold more potent at human 5-HT2C (EC50= 9 nM) than at human 5-HT2A (EC50= 168 nM), and it is 104-fold more potent at human 5-HT2C than human 5-HT2B (EC50= 943 nM). Lorcaserin shows full agonist activity at the human 5-HT2C and 5-HT2B receptors and partial agonist activity at the human 5-HT2A receptor (100%, 100% and 75% of the maximal response elicited by serotonin, respectively). Lorcaserin does not compete for binding of ligands to serotonin, dopamine, and norepinephrine transporters. Lorcaserin does not stimulate norepinephrine, dopamine, or serotonin release from rat synaptosomes at submicromolar concentrations. Lorcaserin weakly inhibits norepinephrine (EC50= 2500 nM), serotonin (EC50= 1400 nM), and dopamine (EC50= 12,000 nM) uptake.


    In VivoLorcaserin produces dose-dependent reductions in food intake and body weight gain during the 4-week study. Lorcaserin (18 mg/kg) significantly increases resting and penile grooming, and has no effects on wet dog shakes, and back muscle contractions of rats. Lorcaserin short-term administration (0.3125-20 mg/kg) significantly reduces nicotine self-administration in female rats. Long-term Lorcaserin (0.625 mg/kg) also significantly reduces nicotine self-administration over a 2-week period of repeated injections. 
    Animal modelRats
    Formulation & Dosage0.3125-20 mg/kg; injections
    ReferencesJ Pharmacol Exp Ther. 2008 May;325(2):577-87; J Pharmacol Exp Ther. 2011 Sep;338(3):890-6.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Lorcaserin HCl
    A, short-term dose-effect function of the higher dose range of lorcaserin on nicotine-self-administration (mean ± S.E.M.). J Pharmacol Exp Ther. 2011 Sep;338(3):890-6. 
     
    Lorcaserin HCl
    A, short-term dose-effect function of the lower dose range of lorcaserin on nicotine-self-administration (mean ± S.E.M.). J Pharmacol Exp Ther. 2011 Sep;338(3):890-6. 
     

    Lorcaserin HCl

    A, chronic lorcaserin administration effect on locomotor activity over 2 weeks of treatment averaged over 12 5-min blocks. J Pharmacol Exp Ther. 2011 Sep;338(3):890-6. 


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?