Lamotrigine (BW430C; LTG)

Alias: BW-430C; Lamotrigine; Lamictal; BW 430C; BW430C; Crisomet; Lamictin; Lamitor
Cat No.:V0998 Purity: ≥98%
Lamotrigine (Lamictal, BW 430C; BW430C; Crisomet, Lamictin, Lamitor), an approved anti-convulsant drug used in the treatment of epilepsy and bipolar disorder, is an inhibitor of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes.
Lamotrigine (BW430C; LTG) Chemical Structure CAS No.: 84057-84-1
Product category: 5-HT Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
25g
Other Sizes

Other Forms of Lamotrigine (BW430C; LTG):

  • Lamotrigine-13C3,d3 (LTG-13C3,d3; BW430C-13C3,d3)
  • Lamotrigine-13C3 (LTG-13C3; BW430C-13C3)
  • Lamotrigine hydrate
  • Lamotrigine-13C,d3
  • Lamotrigine-13C2,15N
  • Lamotrigine-d3 (LTG-d3; BW430C-d3)
Official Supplier of:
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Top Publications Citing lnvivochem Products
Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Lamotrigine (Lamictal, BW 430C; BW430C; Crisomet, Lamictin, Lamitor), an approved anti-convulsant drug used in the treatment of epilepsy and bipolar disorder, is an inhibitor of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes. Moreover, lamotrigine blocks sodium channels.

Biological Activity I Assay Protocols (From Reference)
Targets
Sodium channel; 5-HT (human platelets) ( IC50 = 240 μM ); 5-HT (rat brain synaptosomes) ( IC50 = 474 μM )
ln Vitro

In vitro activity: Lamotrigine prevents the release of excitatory neurotransmitters, especially glutamate and aspartate, by blocking voltage-dependent sodium channels, stabilizing presynaptic neuronal membranes.[1] Lamotrigine inhibits glutamate and aspartate release (ED 50 = 5.38 mg/L for each) in rat cerebral cortex tissue incubated with veratrine 10 mg/L twice as well as GABA release (ED 50 = 11.2 mg/L). However, it is much less effective in inhibiting acetylcholine release (ED 50 = 25.6 mg/L) in cortical slices exposed to veratrine 75 mg/L. There is no change in basal glutamate release.[2] Lamotrigine directly affects voltage-activated sodium channels by inhibiting the high-frequency sustained repetitive firing of sodium-dependent action potentials. [3] Lamotrigine acts by direct inhibition at the NMDA receptor, does not produce effects on the central nervous system (CNS) similar to those of PCP, and is anticipated to be free of side effects related to NMDA blockade. [4]

ln Vivo
Lamotrigine inhibits the hindlimb extension induced by MES and pentetrazol in rats and mice, indicating an antiepileptic effect in these animals. These effects last for longer than 24 hours, peaking one hour after lamotrigine is administered. [4] The electrically evoked EEG after-discharge test shows that lamotrigine is active, which may suggest that it is acting against simple and complex partial seizures. Lamotrigine at intravenous doses greater than 5 mg/kg reduces the after-discharge duration in rats in a dose-dependent manner. [5]
Animal Protocol
Dissolved in 0.25% methylcellulose solution; 4.5 (dogs) and 11.7 (rats) mg /kg; i.v. injection
Dog/Rat
References

[1]. Drugs . 1993 Jul;46(1):152-76.

[2]. Epilepsia . 1986 Sep-Oct;27(5):490-7.

[3]. Epilepsy Res . 1992 Nov;13(2):107-12.

[4]. Epilepsia . 1986 Sep-Oct;27(5):483-9.

[5]. Epilepsia . 1989 Jan-Feb;30(1):34-40.

[6]. Lamotrigine.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C9H7CL2N5
Molecular Weight
256.09
Exact Mass
255.01
Elemental Analysis
C, 42.21; H, 2.76; Cl, 27.69; N, 27.35
CAS #
84057-84-1
Appearance
White to off-white solid powder
SMILES
C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N
InChi Key
PYZRQGJRPPTADH-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
Chemical Name
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Synonyms
BW-430C; Lamotrigine; Lamictal; BW 430C; BW430C; Crisomet; Lamictin; Lamitor
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 10~25 mg/mL (39.0~97.6 mM)
Water: <1 mg/mL
Ethanol: ~3 mg/mL (~11.7 mM)
Solubility (In Vivo)
0.5% methylcellulose: 30 mg/mL
 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.9049 mL 19.5244 mL 39.0488 mL
5 mM 0.7810 mL 3.9049 mL 7.8098 mL
10 mM 0.3905 mL 1.9524 mL 3.9049 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04770493 Recruiting Drug: Lamotrigine
Drug: Placebo
Alcohol Use Disorder Brown University January 24, 2022 Phase 2
NCT05639257 Recruiting Drug: Lamotrigine
Drug: Namuscla
Non-Dystrophic Myotonia Grete Andersen, MD December 5, 2022 Not Applicable
NCT05450978 Recruiting Drug: Lamotrigine
Drug: Levetiracetam
Epilepsy
Pregnancy Related
Page B. Pennell, MD July 20, 2022 N/A
NCT05450822 Recruiting Drug: Levetiracetam
Drug: Lamotrigine tablet
Epilepsy Gitte Moos Knudsen February 18, 2022 N/A
NCT06184581 Not yet recruiting Drug: Lithium Carbonate
Drug: Lamotrigine
Bipolar II Disorder Mental Health Services in the
Capital Region, Denmark
March 1, 2024 Phase 4
Biological Data
  • Lamotrigine
    Concentration-dependent inhibition of lamotrigine on the 5-HT3 receptor currents.Korean J Physiol Pharmacol. 2017 Mar; 21(2): 169–177.
  • Lamotrigine
    Competitive inhibition of lamotrigine on the 5-HT3 receptor currents.Korean J Physiol Pharmacol. 2017 Mar; 21(2): 169–177.
  • Lamotrigine
    Effects of lamotrigine on 5-HT3 receptor deactivation and desensitization.Korean J Physiol Pharmacol. 2017 Mar; 21(2): 169–177.
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