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HDAC

HDAC

HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Structure Cat No. Product Name CAS No. Product Description
V80189 HDAC6-IN-25 HDAC6-IN-25 (compound 8) is a selective HDAC6 inhibitor (antagonist) with IC50 of 0.6 nM.
V80279 HDAC8-IN-5 HDAC8-IN-5 (Compound 6a) is an HDAC8 inhibitor (IC50= 28 nM).
V0265 HPOB 1429651-50-2 HPOB is a novel, potent and selective inhibitor of histone deacetylase 6 (HDAC6) inhibitor with potential anticancer activity.
V80146 J27644 J27644 is a potent HDAC inhibitor.
V80425 JAK/HDAC-IN-2 JAK/HDAC-IN-2 is a potent JAK/HDAC dual-target inhibitor.
V76859 JPS014 TFA JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolytic targeting chimera (PROTAC).
V79999 KH16 KH16 is a potent low nanomolar HDAC inhibitor.
V0266 LMK-235 1418033-25-6 LMK-235 (LMK235) is a novel, potent and selective inhibitor of HDAC4 and HDAC5 (histone deacetylase) with potential antitumor activity.
V0278 M344 (D237; MS344) 251456-60-7 M344(D-237; MS-344),an amide analogue of Trichostatin A, is a novel and potent pan-HDAC (histone deacetylase) inhibitor with potential anticancer activity.
V79624 MAO A/HDAC-IN-1 MAO A/HDAC-IN-1 is a dual (bifunctional) inhibitor of monoamine oxidase A (MAO A) and HDAC.
V0288 MC1568 852475-26-4 MC1568isa hydroxyamide-based inhibitor of class II histone deacetylase (HDAC) such as HDAC4/5/6/7/9 (IIa) and HDAC6/10 (IIb) with potential antiviral activity.
V0259 Mocetinostat (MGCD0103) 726169-73-9 Mocetinostat (formerly MGCD-0103 or MG-0103), is a potent, benzamide-based and orally bioavailable Class I-selective inhibitor of human histone deacetylases (HDAC) with potentianl anticancer activities.
V25955 MPI-5a 1259296-46-2 MPI_5a is a highly efficient and selective HDAC6 inhibitor (IC50=36 nM).
V80866 Mz325 Mz325 is a dual (bifunctional) inhibitor of HDAC and Sirt2, with IC50 of 9.7 μM for Sirt2.
V26320 NCT-14b 956154-63-5 TCS HDAC6 20b is a selective inhibitor of HDAC6.
V0270 Nexturastat A (AG-CR1-3901) 1403783-31-2 Nexturastat A (AG-CR1-3901),an aryl urea analog, is a novel, potent and selective inhibitor of histone deacetylase 6 (HDAC6) with potential anticancer activity.
V0257 Panobinostat (LBH589) 404950-80-7 Panobinostat (formerlyknown as LBH-589 and NVP LBH-589; trade name Farydak)is a novel, potent and broad-spectrum/non-selective/pan-HDAC inhibitor with potential anticancer activity.
V78370 PB94 PB94 is a selective HDAC11 inhibitor (IC50=108 nM).
V0279 PCI-34051 950762-95-5 PCI-34051 is a novel, potent and specific inhibitor of histone deacetylase 8 (HDAC8) with potential anticancer activity.
V77927 PH14 PH14 is a dual PI3K/HDAC inhibitor (antagonist) with IC50s of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively.
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