HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V0258 | Trichostatin A (TSA) | 58880-19-6 | Trichostatin A (also called TSA) is a novel, potent and specific inhibitor of histone deacetylase (HDAC) with potential anticancer activity. |
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V0286 | Tubacin (tubulin acetylation inducer) | 537049-40-4 | Tubacin (known also astubulin acetylation inducer) is a specific HDAC6 (histone deacetylase 6) inhibitor with potential anticancer activity. |
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V0275 | Tubastatin A (TubA, AG-CR1-3900) | 1252003-15-8 | Tubastatin A(TubA, AG-CR13900), a tubacin derivative, is a potent and selective HDAC6 (Histone deacetylase 6) inhibitor (IC50 = 15 nM in a cell-free assay) with potential anticancer and anti-inflammatory activity. |
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V0281 | Tubastatin A HCl (AG-CR-13900, TubA) | 1310693-92-5 | Tubastatin A HCl, the hydrochloride salt ofTubastatin A (also known as TubA, AG-CR-13900), is a tubacin analog that acts as a potentand specificinhibitor of histone deacetylase 6 (HDAC6) with potential antitumor, neuroprotective and anti-inflammatory activities. |
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V79497 | Tucidinostat-d4 (Chidamide-d4; HBI-8000-d4; CS 055-d4) | Tucidinostat-d4 is the deuterium labelled form of Tucidinostat. | |
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V0291 | Valproic acid sodium salt (Sodium valproate) | 1069-66-5 | Valproate (VPA, NSC-93819, valproic acid, sodium valproate, and divalproex sodium) is an approved medication mainly used for the treatment of epilepsy and bipolar disorder, also used to prevent migraine headaches. |
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V78579 | VEGFR2/HDAC1-IN-1 | VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual VEGFR-2/HDAC inhibitor (antagonist) with IC50s of 57.83 nM and 9.82 nM respectively. | |
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V0255 | Vorinostat (SAHA; MK0683) | 149647-78-9 | Vorinostat (formerly known as suberanilohydroxamic acid, MK-0683;CCRIS-8456; HSDB 7930; SAHA; trade name: Zolinza) is a potent,orally bioavailableand non-selective pan-inhibitor of histone deacetylases (HDACs) with antitumor activity. |
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V79187 | WW437 | WW437 is a histone deacetylase (HDAC) inhibitor (antagonist) with potent anti-breast cancer activity both in vivo and in vitro. | |
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V2869 | Zabadinostat (CXD-101; AZD-9468) | 934828-12-3 | HDAC-IN-4 (also known as CXD101,AZD9468) is a novel and potent inhibitor of histone deacetylase (HDAC) with potential anticancer and immunomodulatory activity. |
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V81778 | ZMF-23 | ZMF-23 is a dual PAK1/HDAC6 inhibitor. |
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