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HDAC

HDAC

HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.

HDAC related products

Structure Cat No. Product Name CAS No. Product Description
V0289 Givinostat HCl monohydrate (ITF-2357; Gavinostat)) 732302-99-7 Givinostat (formerly ITF2357; Gavinostat)is a potent andorally bioavailable inhibitor of both class I and class II histone deacetylase (HDAC) with potential anticancer activity.
V78109 GK444 GK444 (Compound 15a) is an HDAC1/2 inhibitor (IC50= 100 and 92 nM for HDAC1/2, respectively).
V78703 GK718 GK718 is an HDAC1/3 inhibitor (IC50= 259 and 139 nM, respectively).
V79732 HDAC-IN-47 HDAC-IN-47 is an orally bioactive histone deacetylase (HDAC) inhibitor (antagonist) with IC50s of 19.75 nM (HDAC1), 5.63 nM (HDAC6), 40.27 nM (HDAC3), and 57.8 nM (HDAC2).
V78726 HDAC-IN-49 HDAC-IN-49 is a potent, non-selective HDAC (HDAC) inhibitor (antagonist) with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4 and HDAC6 respectively.
V78539 HDAC-IN-61 HDAC-IN-61 (compound 12k) is an orally bioavailable HDAC inhibitor.
V79734 HDAC-IN-64 HDAC-IN-64 (Compound 13) is an HDAC inhibitor.
V78305 HDAC-IN-65 HDAC-IN-65 (compound 6) is a selective histone deacetylase (HDAC) inhibitor (antagonist) with IC50 of 2.5μM.
V78616 HDAC-IN-66 HDAC-IN-66 (compound 2F) is a selective HDAC inhibitor and Pomalidomide analogue that effectively inhibits hematological tumor cells.
V79722 HDAC/CD13-IN-1 HDAC/CD13-IN-1 (Compound 12) is an HDAC/CD13 inhibitor (IC50= 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μM for HDAC1/2/3 respectively).
V78660 HDAC1 Degrader-1 HDAC1 Degrader-1 (compound 1a) is an HDAC1 degrader with anti-cancer activity.
V79025 HDAC6-IN-14 HDAC6-IN-14 is a selective HDAC6 (HDAC) inhibitor (antagonist) with IC50 of 42 nM.
V79726 HDAC6-IN-15 HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor.
V79285 HDAC6-IN-16 HDAC6-IN-16 (compound 5c) is a histone deacetylase 6 (HDAC6) inhibitor based on Quinazolin-4(3H)-One.
V79488 HDAC6-IN-17 HDAC6-IN-17 (compound 5b) is a potent HDAC6 inhibitor (antagonist) with IC50s of 150 nM, 1400 nM and 2300 nM for HDAC6, HDAC8 and HDAC4 respectively.
V80137 HDAC6-IN-18 HDAC6-IN-18 (Compound 4) is the first irreversible HDAC6 isoform-selective inhibitor (antagonist) with potent activity against multiple myeloma.
V78754 HDAC6-IN-19 HDAC6-IN-19 (Compound 14g) is an HDAC6 inhibitor (IC50= 2.68 nM).
V79153 HDAC6-IN-22 HDAC6-IN-22 (compound 30) is an inhibitor (blocker/antagonist) of HDAC6 with IC50 of 4.63 nM.
V80190 HDAC6-IN-23 HDAC6-IN-23 (compound 9) is an orally bioactive HDAC6 inhibitor.
V78962 HDAC6-IN-24 HDAC6-IN-24 (compound N1) is an inhibitor (blocker/antagonist) of HDAC6.
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