RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V53398 | Carbazole | 86-74-8 | Carbazole is a tricyclic aromatic heterocycle. |
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V52787 | Carbazole-d8 (carbazole-d8) | 38537-24-5 | Carbazole-d8 is the deuterated form of Carbazole (HY-D0204). |
|
V1425 | Carboplatin | 41575-94-4 | Carboplatin (formerly known as JM-8, CBDCA, NSC-241240; Paraplat; Paraplatin; Blastocarb; Carboplat; Carbosin; Carbosol; Carbotec; Displata; Ercar) is an approved anticancer drug that acts as a DNA synthesis inhibitor by binding to DNA (DNA alkylator) and interfering with the cell's repair mechanism in cancer cells. |
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V5087 | Carmustine (BiCNU) | 154-93-8 | Carmustine (Nitrumon; NSC 409962), anDNA crosslinking and alkylating nitrosourea, is a potent antitumor chemotherapeutic agent. |
|
V52292 | ccc_R08 | 2919019-72-8 | ccc_R08 is a non-cytotoxic, oral cccDNA inhibitor that decreases the amount of cccDNA in HBV-infected mice's livers. |
|
V17878 | CeMMEC13 | 1790895-25-8 | CeMMEC13 is a selective inhibitor of TAF1. |
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V1439 | Chlorambucil (CB-1348) | 305-03-3 | Chlorambucil (CB-1348; WR-139013; CB 1348; WR 139013; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; Leukersan; Leukoran) is an approved antitumor medication mainly used in the treatment of chronic lymphocytic leukemia. |
|
V78776 | Chrexanthomycin C | Chrexanthomycin C is a marine naturally occurring compound with significant bioactivity and is orally bioavailable. | |
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V1444 | Cidofovir (GS 0504) | 113852-37-2 | Cidofovir (also known as HPMPC; GS-0504; HPMPC; (S)-HPMPC; Vistide) is a potent and injectable antiviral medication approved for the treatment of cytomegalovirus (CMV) retinitis with IC50of 0.94 μM. |
|
V1327 | Cisplatin (CDDP) | 15663-27-1 | Cisplatin (CDDP; cis-Diaminodichloroplatinum; Trade names: Platinol; PlatinolAQ among others), an inorganic platinum complex acting as a DNA intercalating agent, is a widely used and classic chemotherapeutic drug and a potent inducer of growth arrest and apoptosisin a variety of cell types. |
|
V1456 | Cladribine | 4291-63-8 | Cladribine (also known as 2-CdA, 2-chlorodeoxyadenosine; Leustatin; Leustat; Leustatine), a purine nucleoside antimetabolite analogue and an approved medication used for treating hairy cell leukemia and B-cell chronic lymphocytic leukemia, is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50s of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
|
V1467 | Clevudine (L-FMAU) | 163252-36-6 | Clevudine (L-FMAU; L FMAU; Levovir and Revovir) is a potent antiviral drug approved in South Korea and the Philippines for the treatment of hepatitis B (HBV) infections with EC50 0.1 μM in HepG2 2.2.15 cells as well as EBV. |
|
V1451 | Clofarabine | 123318-82-1 | Clofarabine(formerly C1 F-Ara-A;C1 F-Ara-A;CAFdA; trade names: Clofarex; Clolar)is an antimetabolite anticancer chemotherapeutic drug and a purine nucleoside approved for the treatment of relapsed or refractory acute lymphoblastic leukemia. |
|
V55175 | COH1 | 20217-22-5 | COH1 is an inhibitor of ribonucleotide reductase (RR). |
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V52218 | Crisnatol (BWA770U) | 96389-68-3 | Crisnatol (BWA770U) is a DNA intercalator based on arylmethylaminopropanediol and an oral active anticancer agent. |
|
V1440 | CRT0044876 | 6960-45-8 | CRT0044876 (CRT-0044876;NSC 69877, 7-NO2-ICA; NSC-69877;CRT 0044876;NSC69877), an indole analog, is a potent and selective APE1 inhibitor with potential antitumor activity. |
|
V1463 | CX-5461 | 1138549-36-6 | CX-5461 (CX 5461; CX5461) is a novel, selective andorally bioavailable inhibitor of rRNA synthesis and rDNA transcription inhibitor with potential antitumor activity. |
|
V4349 | CX-5461 dihydrochloride | CX-5461 dihydrochloride is a novel, potent, selective andorally bioavailable inhibitor of rRNA synthesis, it selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. | |
|
V78930 | Cy5-dATP | Cy5-dATP is Cy5 labeled dATP. | |
|
V1443 | Cyclocytidine HCl (Ancitabine) | 10212-25-6 | Cyclocytidine (formerly NSC-145668;Cyclo-C; NSC145668; Ancitabine) is a pyrimidine nucleoside-basedprodrug of cytarabine that has to be activated through hydrolysis to cytarabine under in vivo conditions. |
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