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Description: Chlorambucil (CB-1348; WR-139013; CB 1348; WR 139013; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; Leukersan; Leukoran) is an approved antitumor medication mainly used in the treatment of chronic lymphocytic leukemia. It acts as an orally-active nitrogen mustard alkylating agent by alkylating and cross-linking DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
References: Arch Biochem Biophys. 2015 Jan 15;566:7-14.
Chemical Name: 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoic acid
InChi Key: JCKYGMPEJWAADB-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
SMILES Code: O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1
CB-1348; WR-139013; CB1348; WR139013; CB 1348; WR 139013; chlorambucilum; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; chloroambucil; chlorobutin; chlorobutine; Leukersan; Leukoran; Lympholysin; phenylbutyric acid nitrogen mustard; US brand names: Ambochlorin; Amboclorin; Leukeran; Linfolizin. Foreign brand names: Altichlorambucil; Chloraminophene; Linfolysin.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
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NMR