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    Chlorambucil (CB-1348)
    Chlorambucil (CB-1348)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1439
    CAS #: 305-03-3Purity ≥98%

    Description: Chlorambucil (CB-1348; WR-139013; CB 1348; WR 139013; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; Leukersan; Leukoran) is an approved antitumor medication mainly used in the treatment of chronic lymphocytic leukemia. It acts as an orally-active nitrogen mustard alkylating agent by alkylating and cross-linking DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. 

    References: Arch Biochem Biophys. 2015 Jan 15;566:7-14.

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    Molecular Weight (MW)304.21 
    FormulaC14H19Cl2NO2 
    CAS No.305-03-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 60 mg/mL (197.2 mM)
    Water: <1 mg/mL
    Ethanol: 60 mg/mL (197.2 mM)
    Other info

    Chemical Name: 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoic acid

    InChi Key: JCKYGMPEJWAADB-UHFFFAOYSA-N

    InChi Code: InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)

    SMILES Code: O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1

    Synonyms

    CB-1348; WR-139013; CB1348; WR139013; CB 1348; WR 139013; chlorambucilum; chloraminophen; Chlorbutin; chlorbutine; chlorbutinum; chloroambucil; chlorobutin; chlorobutine; Leukersan; Leukoran; Lympholysin; phenylbutyric acid nitrogen mustard; US brand names: Ambochlorin; Amboclorin; Leukeran; Linfolizin. Foreign brand names: Altichlorambucil; Chloraminophene; Linfolysin. 


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