RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V3042 | Cycloheximide | 66-81-9 | Cycloheximide, produced by S. griseus, is a glutarimide antibiotic and an inhibitor of protein synthesis in eukaryotes (but not prokaryotes) with IC50 of 5- |
|
V55139 | Cylindrospermopsin | 143545-90-8 | Cylindrospermopsin is a cyanotoxin produced by a variety of freshwater cyanobacteria. |
|
V1459 | Cytarabine | 147-94-4 | Cytarabine (formerly Ara-C; MK-8242; SCH-900242; SCH900242;MK8242; AC-1075; CHX 3311; Arabitin; Aracytidine),a pyrimidine nucleoside analog approved for cancer treatment, is an antimetabolite anticancer drug used mainly for treating leukemia. |
|
V19037 | Cytarabine hydrochloride (MK-8242) | 69-74-9 | Cytarabine hydrochloride (MK-8242; SCH-900242; AC-1075; CHX-3311; Arabitin), thehydrochloride salt of cytarabine, is a pyrimidine nucleoside analog and antimetabolic anticancer agentwith a modified sugar moiety. |
|
V55143 | Cytarabine triphosphate (Ara-CTP) | 13191-15-6 | Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is an inhibitor of DNA synthesis that is competitive. |
|
V53214 | Cytidine 5'-diphosphate trisodium salt (CDP) | 34393-59-4 | Cytidine 5'-diphosphate trisodium salt (CDP) is produced by the transfer of a phosphate group from ATP to cytidine monophosphate (CMP) catalyzed by uridine monophosphate kinase (UMPK). |
|
V40642 | D-I03 | 688342-78-1 | D-I03 (DI03) is a novel and potent RAD52 inhibitor (Kd= 25.8 µM) with anticancer activity. |
|
V55126 | D-Xylofuranose, 1,2,3,5-tetraacetate | 42927-46-8 | D-Xylofuranose, 1,2,3,5-tetraacetate is a raw material used in the preparation /synthesis of nucleotides. |
|
V1458 | Dacarbazine (DTIC) | 4342-03-4 | Dacarbazine (formerly also known as DTIC, DTIC-Dome; WR-139007; Asercit; Dacatic; Deticene) is an antitumor chemotherapeutic drug approved by FDA in the 1970s for the treatment of various cancers, including advanced melanoma (major use), Hodgkin lymphoma, sarcoma, and islet cell carcinoma of the pancreas. |
|
V5111 | Dactinomycin (Actinomycin IV; Actinomycin D) | 50-76-0 | Dactinomycin (Actinomycin IV; Actinomycin D), a compound of the actinomycine class, is a polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. |
|
V75894 | DAM-IN-1 | 935279-95-1 | DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50= 48 μM. |
|
V53553 | Danofloxacin-d3 (Danofloxacin d3) | 1825377-28-3 | Danofloxacin-d3 is the deuterated form of Danofloxacin. |
|
V1476 | Daphnetin (7,8-dihydroxycoumarin) | 486-35-1 | Daphnetin (NSC-633563; NSC633563; 7,8-dihydroxycoumarin), a naturally occuring coumarin analog isolated from plants of the genus Daphne, is a PKI-protein kinase inhibitor with important biological activity (e.g. anti-inflammatory and anti-oxidant effects). |
|
V1453 | Daptomycin (LY146032) | 103060-53-3 | Daptomycin (also known as LY146032; LY-146032; trade name: Cubicin; Cidecin),a natural product isolated from the soil saprotroph Streptomyces roseosporus,is a novel lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. |
|
V2747 | Darusentan | 171714-84-4 | Darusentan (formerly LU-135252 or HMR-4005) is an endothelin receptor antagonist (ERA)/inhibitor. |
|
V4645 | Datelliptium chloride | 105118-14-7 | Datelliptium chloride, aellipticine derivative, is a novel and potent DNA-intercalating agent with anti-cancer activities. |
|
V21607 | Datelliptium chloride hydrochloride | 157000-76-5 | Datelliptium chloride hydrochloride is a DNA chimeric agent derived from Ellipticine (HY-15753). |
|
V80432 | ddTTP trisodium | ddTTP trisodium is a class of dideoxyribonucleotides (ddNTPs) that may be utilized in DNA sequencing as a DNA polymerase chain elongation inhibitor. | |
|
V75895 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | 1262896-48-9 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK is a Mithramycin analogue with good anti-tumor activity. |
|
V54168 | DENV-IN-2 | 2253675-62-4 | DENV-IN-2 is a dengue viral replication inhibitor with an EC50 of 0.016 nM. |
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