RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1427 | 6-Thio-dG (β-TGdR) | 789-61-7 | 6-thio-dG (β-TGdR; 6-Thio-2-Deoxyguanosine; BetaTGdR) is a nucleoside analog anda potent telomerase-mediated telomere disrupting compound with potential antitumor activity. |
|
V53052 | 7-Deaza-2'-deoxy-7-iodoadenosine | 166247-63-8 | Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine. |
|
V53322 | 7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) | 172163-62-1 | 7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a deoxyguanosine analogue that may be utilized in DNA synthesis and sequencing reactions. |
|
V55153 | 7-Methyl-diguanosine triphosphate (m7Gp3G) | 62828-64-2 | 7-Methyl-diguanosine triphosphate (m7Gp3G) is a cap analog that helps with translation and mRNA degradation. |
|
V54322 | Abyssinone V | 77263-11-7 | Abyssinone V is a prenylated flavonoid with predicted antiviral activity. |
|
V52932 | Ac-rC Phosphoramidite (N-acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine- 3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite) | 121058-88-6 | Ac-rC Phosphoramidite can be used for phosphodithio-oligonucleotide (PS2-RNA) modification. |
|
V1449 | Adenine (6-Aminopurine) | 73-24-5 | Adenine (formerly NSC 14666; NSC-14666; NSC14666; 6-Aminopurine; Vitamin B4),one of the four chemical/nucleobases in DNA, is a purine derivative and a nucleobase with a variety of functions in biochemistry. |
|
V1450 | Adenine HCl | 2922-28-3 | Adenine HCl(6-Aminopurine; Vitamin B4; NSC 14666; NSC-14666),the hydrochloride salt of adenine, is apurine analogand an adenine receptor agonist with a Ki of 18 nM at rat adenine receptors. |
|
V1470 | Adenine sulfate | 321-30-2 | Adenine sulfate (6-Aminopurine hemisulfate; Vitamin B4 hemisulfate), the sulfate salt form of adenine, is a purine derivative and a nucleobase with important biological functions. |
|
V30885 | AGX51 | 330834-54-3 | AGX51 is the first pan-Id (inhibitors of DNA-binding/differentiation proteins) antagonist and degrader. |
|
V52431 | Albomycin | 1414-39-7 | Albomycin is an aminoacyl-tRNA synthetase inhibitor with a Trojan horse effect. |
|
V4727 | Alovudine | 25526-93-6 | Alovudine (MIV310;CL-184824; 3-Fluoro-3-deoxythymidine) is a novel and potent reverse transcriptase inhibitor (RTI) with the potential for the treatment of HIV infection. |
|
V34862 | Antibacterial agent 124 | 2304448-00-6 | Antibacterial agent 124 (Compound 3) is a novel bacterial proline-tRNA synthetase (ProRS) inhibitor that inhibits Staphylococcus aureus ProRS (SaProRS) with an IC50 of 0.18 μM. |
|
V75898 | Antitumor agent-74 | 2827065-28-9 | Antitumor agent-74 is a quinazoline analogue and antitumor agent. |
|
V78303 | Antiviral agent 36 | antiviral compound 36 (compound 27) is a potent inhibitor of dengue (DENV) and Zika (ZIKV) viruses. | |
|
V52402 | Ara-ATP | 3714-60-1 | Ara-ATP is a structural analog of ATP that can inhibit poly(A) polymerase activity by competing with ATP. |
|
V52395 | ART812 | 2607138-82-7 | ART812 is an orally available inhibitor of DNA polymerase Polθ with an IC50 value of 7.6 nM. |
|
V2746 | Azoxystrobin | 131860-33-8 | Azoxystrobin(brand name Amistar, Syngenta) is a very important andsystemic fungicide commonly used in agriculture. |
|
V78327 | AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) | AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is an active triphosphate metabolite of Zidovudine (AZT). | |
|
V2700 | B02 | 1290541-46-6 | B02 (also called RAD51-IN-02)is a potent and specific inhibitor of human RAD51 with an IC50of 27.4 μM. |
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