One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3837 | GSK2110183 | 1047634-63-8 | GSK2110183, an analog ofAfuresertib, is a potent, orally bioavailable andATP-competitive Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. |
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V4633 | GSK2110183 HCl | 2070009-64-0 | GSK2110183 HCl, an analog ofAfuresertib, is a potent, orally bioavailable andATP-competitive Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. |
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V69830 | H-Ile-Lys-Val-Ala-Val-OH | 131167-89-0 | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of lamin-1. |
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V69802 | Insulin Detemir | 169148-63-4 | Insulin Detemir is an artificial insulin that controls blood sugar levels. |
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V0158 | Ipatasertib (GDC0068; RG7440) | 1001264-89-6 | Ipatasertib (formerly also called GDC-0068; RG-7440) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with potential anticancer activity. |
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V33006 | Ipatasertib dihydrochloride (GDC-0068) | 1396257-94-5 | Ipatasertib dihydrochloride (formerly also called GDC-0068) is a novel, potent, orally bioavailable, ATP-competitive and highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM in cell-free assays, it showed 620-fold selectivity over PKA. |
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V33314 | K-80003 | 1292821-90-9 | K-80003 effectively inhibits tRXRα-dependent Akt activation and tumor cell growth. |
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V51338 | Kihadanin B | 73793-68-7 | citrus limonoidl inhibitor of Akt-FOXO1-PPARγ axis |
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V0166 | Miltefosine (Impavido; HePC) | 58066-85-6 | Miltefosine(Impavido; HePC), an alkyl-phosphocholine compound, is a potent,orally- and topically-bioactive,broad spectrum antimicrobial and anti-leishmanial medication that also haspotential antineoplastic activity. |
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V3318 | Miransertib HCl (ARQ 092; MK-7075) | 1313883-00-9 | Miransertib HCl (formerly known as ARQ-092; MK7075), the HCl salt ofMiransertib, is a novel, orally bioactive and selective allosteric inhibitor of AKT anticancer activity. |
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V0155 | MK-2206 2HCl | 1032350-13-2 | MK-2206 dihydrochloride (2HCl) is a novel, potent, orally bioavailable and highly selective allosteric inhibitor of the serine/threonine protein kinase Akt1/2/3 with potential anticancer activity. |
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V25651 | ML 9 HCl salt | 105637-50-1 | ML-9 HCl is a novel, potent and selective myosin light chain kinase (MLCK) inhibitor, also Akt kinase andand stromal interaction molecule 1 (STIM1). |
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V70204 | Monomethyl lithospermate (Lithospermic acid monomethyl ester) | 933054-33-2 | Monomethyl lithospermate activates the PI3K/AKT pathway and exerts a protective effect on nerve damage. |
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V82333 | N1,N8-Diacetylspermidine hydrochloride | 178244-42-3 | N1,N8-Diacetylspermidine HCl is a polyamine found in human urine. |
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V1990 | Oridonin (NSC-250682) | 28957-04-2 | Oridonin (NSC-250682; Isodonol) is a novel, naturally occurring and cell-permeable diterpenoid extracted from Rabdosia rubescens with anticancer activity. |
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V0156 | Perifosine (KRX0401) | 157716-52-4 | Perifosine(also known as KRX-0401)is a potent, orally bioavailable and synthetic antitumor alkylphospholipid (APL) which acts as an Akt inhibitor and a PI3K inhibitor with potential anticancer activity. |
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V0123 | PF-04691502 | 1013101-36-4 | PF-04691502 is a novel, potent, ATP-competitive and selective dual inhibitor of PI3K (phosphatidylinositol 3 kinase) and mTOR (mammalian target of rapamycin) with potential anticancer activity. |
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V4482 | PF-AKT400 | 1004990-28-6 | PF-AKT400 (AKT-0286; ZINC-111606147), designed based on a 3-aminopyrrolidine scaffold, is a novel, selective, potent, ATP-competitiveAkt kinase inhibitor with antitumor activity. |
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V0165 | PHT-427 (CS-0223) | 1191951-57-1 | PHT-427(CS0223) is a novel, potent, orally bioactive and dual inhibitor of Akt and PDPK1 (PtdIns dependent protein kinase-1) with potential anticancer activity. |
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V78942 | PI3K-IN-48 | PI3K-IN-48 is a PI3K inhibitor (antagonist) with IC50 of 1.55 ± 0.18 μM on A549 cells. |
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