One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V30865 | Recilisib | 334969-03-8 | Recilisib (ON-01210; ON 01210; ON01210; EX-RAD) is a novel and potent radioprotectant undergoingphase I clinical trials by Onconova Therapeutics for the treatment of acute radiation syndrome. |
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V70209 | Reptoside | 53839-03-5 | Reptoside is an iridoid glycoside that is a DNA damaging agent. |
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V0074 | SC66 | 871361-88-5 | SC66 is a novel, potent and allosteric inhibitor of AKT with potential anticancer activity, itreduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells. |
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V0171 | SC79 | 305834-79-1 | SC79 is a novel, potent,selective, cell-permeable, and brain-penetrable activator of Akt phosphorylation with the potential to be used to enhance Akt activity in various physiological and pathological conditions, e. |
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V15181 | SPP-86 | 1357349-91-7 | SPP-86 is a potent and selective inhibitor of RET tyrosine kinase with IC50 of 8 nM. |
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V56156 | Tanshinol borneol ester | 1623012-10-1 | Tanshinol borneol ester is an angiogenesis stimulator that promotes multiple key steps of angiogenesis through the Akt and MAPK signaling pathways. |
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V70215 | TAT-TCL1-Akt-in | 1073630-46-2 | TAT-TCL1-Akt-in is an Akt inhibitor. |
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V70210 | TCL1(10-24) | 835655-37-3 | TCL1(10-24) is the betaA chain of human TCL1. |
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V0172 | TIC10 (imipridone, ONC201, NSC350625) | 1616632-77-9 | TIC10(ONC-201, NSC-350625), an imipridone compound,isa novel, potent, orally bioavailable, brain/BBB penetrant, and stable tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)inducer with potential anticancer activity. |
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V0168 | TIC10 Analogue (ONC-201 isomer) | 41276-02-2 | TIC10 Analogue (ONC201 isomer) is an analog/isomer of TIC10 and the inactive form of TIC10. |
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V82334 | Trichloroacetic acid | 76-03-9 | Trichloroacetic acid is a extensively usedfacial resurfacing agent. |
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V0162 | Triciribine (API2; NSC 154020; VQD002) | 35943-35-2 | Triciribine (also known as API-2; NSC-154020; VQD-002), a cell-permeable tricyclic nucleoside molecule, is a potent DNA synthesis inhibitor with potential anticancer activity. |
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V3838 | Uprosertib (GSK2141795) | 1047634-65-0 | Uprosertib (formerly known as GSK2141795 and GSK795), an analog ofGSK2110183, is a potent, orally bioavailable andATP-competitive Akt inhibitor with IC50 values of 180 nM, 328 nM, and 38 nM for Akt1/Akt2/Akt3, respectively. |
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V3839 | Uprosertib (GSK2141795) HCl | 1047635-80-2 | Uprosertib (formerly known as GSK2141795 and GSK795), an analog ofGSK2110183, is a potent, orally bioavailable andATP-competitive Akt inhibitor with IC50 values of 180 nM, 328 nM, and 38 nM for Akt1/Akt2/Akt3, respectively. |
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V3410 | YS 49 | 132836-42-1 | YS-49 (YS49) is a novel and potent anti-inflammatory agent and activator of PI3K/Akt signaling with the potential to be used for treating vascular diseases such as hypertension and atherosclerosis. |
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V70197 | ZINC00640089 | 667880-11-7 | ZINC00640089 is a specific lipocalin-2 (LCN2) inhibitor. |
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V9999998 | 危险化学品管理系统0000 |
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