One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.
There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V77873 | Akt/SKG Substrate Peptide TFA | Akt/SKG Substrate Peptide TFA is a synthetic Akt/PKB substrate peptide that is not phosphorylated by p70S6K or MAPK1. | |
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V70202 | Akt3 degrader 1 | 2836342-69-7 | Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that can overcome Osimertinib-induced resistance of H1975OR NSCLC cells. |
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V0173 | Akti-1/2 (AKT inhibitor VIII) | 612847-09-3 | Akti-1/2 (known also as AKT inhibitor VIII), aquinoxaline-based compound,is a novel, potent, selective,cell-permeable and allosteric inhibitor of Akt1/2 with potential anticancer activity. |
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V77874 | AKTide-2T TFA | AKTide-2T TFA is an excellent in vitro AKT substrate that competitively inhibits histone H2B phosphorylation with a Ki of 12 nM. | |
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V79677 | Antiangiogenic agent 4 | Antiangiogenic agent 4 (Compound 3b) inhibits Akt phosphorylation in HFF and HUVEC cells. | |
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V11457 | API-1 | 36707-00-3 | API-1 (API1) is a novel and potent Akt inhibitor, inducing GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis. |
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V70212 | APN/AKT-IN-1 | 2854340-31-9 | APN/AKT-IN-1 is a potent dual (bifunctional) inhibitor of APN and AKT with IC50s of 0.21 and 0.27 μM, respectively. |
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V70206 | Artemisiane E | 2618700-77-7 | Artemisiane E (Compound 8) is a potent inhibitor of the PI3K/AKT pathway with IC50 of 8.9 μM. |
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V0170 | AT13148 | 1056901-62-2 | AT13148 is a novel, potent, orally bioavailable, ATP-competitive, multi-AGC kinase inhibitor with potential anticancer activity. |
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V0161 | AT7867 | 857531-00-1 | AT7867 isa novel, highly potent, orally bioavailable and ATP-competitive inhibitorofAkt1/Akt2/Akt3andp70S6K/PKA (protein kinase A) with potential anticancer activity. |
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V11795 | AT7867 Dihydrochloride | 1431697-86-7 | AT7867 Dihydrochloride is a novel, highly potent and ATP-competitive inhibitor of Akt1/Akt2/Akt3 and p70S6K/PKA with IC50s of 32 nM/17 nM/47 nM and 85 nM/20 nMin cell-free assays, respectively. |
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V4127 | BAY-1125976 | 1402608-02-9 | BAY1125976 (BAY-1125976) is a novel, orally bioavailable andselective allosteric inhibitor of Akt1/Akt2 with potential anticancer activity. |
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V4274 | Capivasertib | 1143532-39-1 | Capivasertib (formerly known as AZD5363), a novel pyrrolopyrimidine-derived compound, is a potent,orally bioavailablepan-AKTkinase inhibitor with potential anticancer activity. |
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V0163 | CCT128930 | 885499-61-6 | CCT128930 is a novel, potent, ATP-competitive and selective pyrrolopyrimidine-basedinhibitor of Akt2 (IC50 = 6 nM in a cell-free assay)with potential anticancer activity. |
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V18788 | Crebanine | 25127-29-1 | Crebanine is a novel and potent bioactive compound. |
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V18860 | CTX-0294885 | 1439934-41-4 | CTX-0294885 is a novel potent and broad-spectrum kinase inhibitor and a sepharose-supported kinase capture reagent which exhibits inhibitory activity against a broad range of kinases in vitro. |
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V77130 | CTX-0294885 hydrochloride | CTX-0294885 HCl is a broad-spectrum kinase inhibitor that captures 235 kinases from MDA-MB-231 cells and captures all members of the AKT family. | |
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V70208 | Dehydrovomifoliol | 39763-33-2 | Dehydrovomifoliol is a dual (bifunctional) inhibitor of AKT/mTOR. |
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V19575 | Esculetin | 305-01-1 | Esculetin is a naturally occuring β-catenin inhibitor found mainly in chicory and other plant sources with antioxidant, antiinflammatory, and antitumor activities. |
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V0157 | GSK-690693 | 937174-76-0 | GSK690693, an aminofurazan derivative, is a novel, potent andATP-competitivepan-Akt inhibitor targeting Akt1/2/3 with potential anticancer activity. |
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