Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V72065 | Tadalafil-d3 (IC-351-d3) | 960226-55-5 | Tadalafil-d3 is the deuterium labelled form of Nortadalafil. |
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V72044 | Theodrenaline hydrochloride ((±)-Theodrenaline hydrochloride) | 2572-61-4 | Theodrenaline HCl is a cardiotonic agent and is often mixed with Cafedrine in proportion to form Akrinor, which has a blood pressure lowering effect. |
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V72026 | Thioquinapiperifil dihydrochloride (KF31327) | 204077-66-7 | Thioquinapiperifil di-HCl (KF31327) is a specific, noncompetitive (IC50 of 0.074 nM) inhibitor of phosphodiesterase (PDE-5) for studies of sexual maturation. |
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V16347 | THPP-1 | 1257051-63-0 | THPP-1 is a novel, potent and orally bioavailable PDE10A (phosphodiesterase 10A) inhibitor withKi values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. |
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V72016 | TMX-4100 | 2367619-63-2 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. |
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V72085 | Toddacumalone | 139750-79-1 | Toddacoumalone is a natural phosphodiesterase 4 (PDE4) inhibitor (antagonist) with moderate potency and imperfect active molecule-like properties. |
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V72034 | TPN729 | 936951-20-1 | TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
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V72036 | TPN729MA (TPN729 maleate) | 1422955-52-9 | TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
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V72011 | Trequinsin hydrochloride (HL 725) | 78416-81-6 | Trequinsin HCl (HL 725) is a potent inhibitor of platelet CAMP phosphodiesterase (PDE) with IC50 of 0.25 nM. |
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V72045 | Udenafil-d7 (Udenafil d7) | 1175992-76-3 | Udenafil-d7 is the deuterium labelled form of Udenafil. |
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V31439 | Vardenafil HCl | 224785-91-5 | Vardenafil HCl, also known as BAY 38-9456 HCl,is a novel and potent PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
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V27984 | Vesnarinone (OPC8212) | 81840-15-5 | Vesnarinone (OPC-8212) is a quinolinone-based cardiotonic agent, acting as a mixed phosphodiesterase 3 (PDE3) inhibitor and ion-channel modifier with modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. |
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V72037 | Vinpocetine-d5 (vinpocetine d5) | 2734920-39-7 | Vinpocetine-d5 is the deuterium labelled form of Vinpocetine. |
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V12983 | W-7 HCl | 61714-27-0 | W-7 HCl is a novel, potent and selective calmodulin antagonist with antitumor activity. |
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V72029 | Yonkenafil (Tunodafil) | 804518-63-6 | Yonkenafil (Tunodafil) is a novel phosphodiesterase 5 (PDE5) inhibitor that is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. |
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V83235 | Z21090 (ZL40) | 2992690-71-6 | Z21090 (ZL40) is a novel PDE4 inhibitor with IC50 of 37.4 nM, may be used in the research of alcohol-related diseases. |
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V8408 | Zaprinast | 37762-06-4 | Zaprinast is apotentphosphodiesterase (PDE) inhibitor withselectivityfor PDE5, PDE6, PDE9 and PDE11 andIC₅₀ values of 0.76, 0.15, 29.0, and 12.0 μM, respectively. |
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V24190 | Zardaverine | 101975-10-4 | Zardaverine is a novel and selective PDE (Phosphodiesterase) 3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively. |
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V72009 | Zatolmilast (BPN14770) | 1606974-33-7 | Zatolmilast (BPN14770) is a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) with IC50s of 7.8 nM for PDE4D7 and 7.4 nM for PDE4D3. |
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V60039 | Siguazodan | 115344-47-3 | Siguazodan, also known as SKF 94836, is an orally active phosphodiesterase III (PDE-III) inhibitor. It's IC50 & Target is 117 nM. |
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