Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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Targets |
PDE5 0.074 nM (IC50) PDE1 380 nM (IC50) PDE2 670 nM (IC50) PDE3 38 nM (IC50) PDE4 800 nM (IC50)
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ln Vitro |
Dietary supplements contain thioquinapiperifil [1]. Platelet aggregation is inhibited by thioquinapiperifil dihydrochloride (KF31327) at concentrations ranging from 0.1 to 10 μM. Higher doses of Thioquinapiperifil dihydrochloride (KF31327), at 1 and 10 μM, are necessary to prevent platelet aggregation in the absence of nitroglycerin[2]. At 10 μM, thioquinapiperifil dihydrochloride (KF31327) exhibits a notable rise in cyclic GMP. Thioquinapiperifil dihydrochloride (KF31327)-treated cells have mean cyclic GMP levels of 0.95±0.17 pmol/108 cells after 5 min incubation[2].
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References |
[1]. Nahoko Uchiyama, et al. Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement. Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1331-4.
[2]. R Hirose, et al. KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5. Eur J Pharmacol. 2001 Nov 9;431(1):17-24. |
Molecular Formula |
C24H30CL2N6OS
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Molecular Weight |
521.51
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CAS # |
204077-66-7
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Related CAS # |
Thioquinapiperifil;220060-39-9
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SMILES |
Cl.Cl.OCC1CCN(C2=CC=CC=C2CNC2=NC=NC3=CC4N(CC)C(=S)NC=4C=C23)CC1
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 125 mg/mL (239.69 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (3.99 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (3.99 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9175 mL | 9.5875 mL | 19.1751 mL | |
5 mM | 0.3835 mL | 1.9175 mL | 3.8350 mL | |
10 mM | 0.1918 mL | 0.9588 mL | 1.9175 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.