Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V18975 | Lodenafil | 139755-85-4 | Lodenafil (also known as hydroxyhomosildenafil; trade name Helleva), an analog of sildenafil, is a novel and potent phosphodiesterase PDE5 inhibitor with the potential to treat erectile dysfunction (ED). |
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V24871 | m-3M3FBS | 200933-14-8 | m-3M3FBS is a potent activator of phospholipase C (PLC). |
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V72041 | Mangostanol ((+)-Mangostanol) | 184587-72-2 | Mangostanol ((+)-Mangostanol) is a polyoxone mangostanol extracted from the husks of Garcinia mangosteen and displays inhibitory effects on cAMP phosphodiesterase (PDE). |
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V72018 | Mardepodect hydrochloride (PF-2545920 hydrochloride) | 2070014-78-5 | Mardepodect HCl (PF-2545920 HCl) is a potent, orally bioactive, and selective inhibitor of PDE10A with IC50 of 0.37 nM, which is more than 1000 times more selective than other PDEs. |
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V2330 | MBCQ | 150450-53-6 | MBCQ is a potent and specific cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor (antagonist) with IC50 of 19 nM. |
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V71185 | Mesembrine ((+)-Mesembrine) | 468-53-1 | Mesembrine ((+)-Mesembrine) A major alkaloid with an aryloctahydroindole skeleton. |
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V79506 | MEY-003 | MEY-003 is an inhibitor targeting Autotaxin (ATX) with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ, respectively (analyzed using LPC18:1). | |
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V4018 | ML-030 | 1013750-77-0 | ML-030 (CID-11757146) is a novel potent and selective PDE4inhibitor withIC50values of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. |
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V72012 | MR-L2 | 2374703-19-0 | MR-L2 is a reversible, noncompetitive long-form phosphodiesterase-4 (PDE4) activator of representative PDE4 long-form isoforms (PDE4A4, PDE4B1, PDE4C3, PDE4D5) . |
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V72038 | Mufemilast (Hemay005) | 1255909-03-5 | Mufemilast is an inhibitor (blocker/antagonist) of phosphodiesterase 4 (PDE4). |
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V3322 | MY 5445 | 78351-75-4 | MY-5445 is a potent inhibitor of platelet aggregatio. |
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V72021 | N-Desmethyl Sildenafil (Desmethylsildenafil; UK-103,320) | 139755-82-1 | N-Desmethyl Sildenafil (Desmethylsildenafil) is the major metabolite of Sildenafil. |
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V72010 | Nerandomilast (BI 1015550) | 1423719-30-5 | Nerandomilast (BI 1015550) is an orally bioactive PDE4B inhibitor (antagonist) with IC50 of 7.2 nM. |
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V80928 | Nerandomilast dihydrate (BI 1015550 dihydrate) | Nerandomilast (BI 1015550) dihydrate is an orally bioactive PDE4B inhibitor (antagonist) with IC50 of 7.2 nM. | |
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V72049 | Nor-Acetildenafil | 949091-38-7 | Nor-Acetildenafil is an Acetildenafil analogue. |
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V72052 | Norbraylin (Norbraylin) | 60796-64-7 | Norbraylin is a natural prenylated coumarin and a PDE4D2 inhibitor (antagonist) with IC50 of 7.15 μM. |
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V32319 | Nortadalafil | 171596-36-4 | Nortadalafil (Demethyl Tadalafil) is thedemethylated metabolite/impurity of Tadalafil, which is a potent PDE5 inhibitor approved as an oral drug for treating erectile dysfunction (ED). |
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V72093 | PAT-347 | 1689554-51-5 | PAT-347 is an Autotaxin (ATX) inhibitor. |
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V72035 | PDE1-IN-3 | 2370966-46-2 | PDE1-IN-3, compound 4 (WO2019156861), is a selective inhibitor of human phosphodiesterase 1 (PDE1). |
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V78586 | PDE1-IN-5 | PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50= 15 nM). |
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