Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V70356 | Fenspiride | 5053-06-5 | Fenspiride is an orally bioactive non-steroidal anti-inflammatory agent and an antagonist of H1-histamine receptors. |
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V2994 | Flavoxate | 15301-69-6 | Flavoxate is an anticholinergic (AChR) agent that binds and inhibits muscarinic receptors, thereby suppressing the micturition reflex and increases urinary bladder capacity by modifying the micturition center in the brain stem. |
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V72073 | Gemlapodect (RO554965) | 1380329-87-2 | Gemlapodect (RO554965) is a phosphodiesterase 10A (PDE10A) inhibitor. |
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V72025 | Gisadenafil besylate (UK 369003-26) | 334827-98-4 | Gisadenafil besylate (UK 369003-26) is a specific, orally bioactive phosphodiesterase 5 (PDE5) inhibitor (antagonist) with IC50 of 3.6 nM that prevents the degradation of cyclic guanosine monophosphate (cGMP). |
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V32938 | GSK 256066 Trifluoroacetate | 1415560-64-3 | GSK256066 Trifluoroacetate (GSK256066; GSK-256066), thetrifluoroacetic acid salt form ofGSK256066, is a novel selective inhibitor of PDE4B (phosphodiesterase 4B) with important biological activity (e. |
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V3384 | HA130 | 1229652-21-4 | HA130 (HA-130) is a novel, potent and selective inhibitor of autotaxin (ATX, IC50 = 28 nM) with anticancer activity. |
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V76937 | Hcyb1 | Hcyb1 is a selective, orally bioactive PDE2 inhibitor. | |
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V72059 | Homo Sildenafil | 642928-07-2 | Homo Sildenafil is an analog of Sildenafil that works as a phosphodiesterase inhibitor. |
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V4097 | IBMX | 28822-58-4 | IBMX is anonspecific, broad-spectrum, competitive inhibitor of phosphodiesterase (PDE) inhibitor, withIC50s of 6.5, 26.3 and 31.7 μM forPDE3,PDE4andPDE5, respectively. |
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V72051 | Ibudilast-d7-1 (KC-404-d7-1; AV-411-d7-1; MN-166-d7-1) | 1204192-90-4 | Ibudilast-d7-1 is the deuterium labelled form of Ibudilast. |
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V72040 | Ilexsaponin B2 (Ilexsaponin B2; Ilex saponin B2) | 108906-69-0 | Ilexsaponin B2 is a saponin extracted from Ilex pubescens Hook. |
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V72027 | Irsenontrine (E2027) | 1429509-82-9 | Irsenontrine (E2027) is an orally bioactive and selective phosphodiesterase 9 (PDE9) inhibitor. |
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V72094 | Irsenontrine maleate (E2027 maleate) | 1630083-70-3 | Irsenontrine (E2027) maleate is an orally bioactive and selective phosphodiesterase 9 (PDE9) inhibitor. |
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V72063 | Isopedicin | 4431-42-9 | Isopedicin potently and concentration-dependently inhibits the production of superoxide anion (O2 U?) in formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-activated cells. |
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V22773 | ITI-214 phosphate | 1642303-38-5 | ITI-214 is an orally bioavailable, potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. |
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V2209 | K-Ras-PDEδ-IN-1 | 1841464-21-8 | K-Ras-PDEδ-IN-1 is a novel and potent competitiveK-Ras-PDEδinhibitor. |
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V72030 | Kuraridine (Hypomatrine) | 34981-25-4 | Kuraridine is a ketol extract obtained from Sophora flavescens root. |
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V72060 | Kushenol B | 99217-64-8 | Kushenol B is an isoprenoid flavonoid extracted from S. flavescens and has antibacterial, anti-inflammatory and antioxidant activities. |
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V72022 | LEO 39652 | 1445656-91-6 | LEO 39652 is a dual-soft PDE4 inhibitor (antagonist) with IC50s of 1.2 nM for PDE4A, 1.2 nM for PDE4B, 3.0 nM for PDE4C, and 3.8 nM for PDE4D. |
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V24041 | Levosimendan | 141505-33-1 | Levosimendan (trade name Simdax) is a novel and potent calcium sensitizer that has been used in the management of acutely decompensated congestive heart failure. |
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