Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72057 | PF-03049423 free base | 954138-07-9 | PF-03049423 (Compound PF-5) free base is a specific inhibitor of phosphodiesterase-5A with IC50 of approximately 0.2 nM against rat and human platelet enzymes. |
|
V4469 | PF-04957325 | 1305115-80-3 | PF-04957325 (PF04957325) is a novel, highly potent and selectivePDE8inhibitor with important biological activity. |
|
V4477 | PF-05085727 | 1415637-72-7 | PF-05085727 (PF05085727) is a novel, highly potent, selective and brain penetrantPhosphodiesterase 2A (PDE2A)inhibitor (IC50 = 2 nM) with the potential to be used for cognition disorders. |
|
V4447 | PF-05180999 | 1394033-54-5 | PF-05180999 is aphosphodiesterase 2A (PDE2A)inhibitor, with anIC50of 1.6 nM. |
|
V72061 | Phenacaine (Holocaine) | 101-93-9 | Phenacaine (Holocaine) is a local anesthetic. |
|
V72031 | Phosphodiesterase (PDE) | 9025-82-5 | Phosphodiesterase (PDE) is an enzyme that can catalyze the hydrolysis of the 3' ring phosphate bond of cyclic nucleotides and is widely used in biochemical research. |
|
V72080 | Phosphodiesterase II | 9068-54-6 | Phosphodiesterase II, phosphodiesterase 2, is mainly involved in hydrolyzing the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), and is widely utilized in biochemical research. |
|
V72055 | Phosphodiesterase-IN-1 | 521297-42-7 | Phosphodiesterase-IN-1 (Compound 7) is a phosphodiesterase (PDE) inhibitor (antagonist) with anti-Plasmodium activity. |
|
V3496 | Piclamilast | 144035-83-6 | Piclamilast is a novel potent,andselective PDE4 inhibitor. |
|
V13255 | Propentofylline | 55242-55-2 | Propentofylline (HWA285; HWA-285; HWA 285; Karsivan;Hextol; Propentophylline), a xanthine derivative,is a potent phosphodiesterase (PDE) inhibitorwith potential neuroprotective activity. |
|
V13925 | Ro20-1724 | 29925-17-5 | Ro 20-1724 (Ro 20-174) is a potent cAMP-specific phosphodiesterase inhibitor (PDE4/PDE IV) with Ki of 1930 nM. |
|
V13970 | Roflumilast N-oxide | 292135-78-5 | Roflumilast N-oxide is a phosphodiesterase 4 inhibitor. |
|
V56171 | Roflumilast-d4 (APTA-2217-d4; BYK 20869-d4; B9302-107-d4) | 1398065-69-4 | Roflumilast-d4 is the deuterium labelled form of Roflumilast. |
|
V56170 | Roflumilast-d4 N-Oxide (Roflumilast d4 (N-oxide)) | 1794760-31-8 | Roflumilast-d4 N-Oxide is the deuterium labelled form of Roflumilast. |
|
V72082 | S32826 | 1096770-84-1 | S32826 is a potent autotaxin inhibitor (antagonist) with IC50 of 8.8 nM. |
|
V4198 | Sildenafil | 139755-83-2 | Sildenafil (formerly UK92480; UK-92480;Trade name: Revatio), the free base form of Sildenafil, is a potentandselective inhibitor of phosphodiesterase type 5 (PDE5) withIC50of 5.22 nM. |
|
V72050 | Sildenafil-d3 (UK-92480-d3) | 1126745-90-1 | Sildenafil-d3 is deuterium-labeled sildenafil. |
|
V72087 | Sildenafil-d3N-1 (UK-92480-d3N-1) | 1126745-87-6 | Sildenafil-d3-1 (UK-92480-d3-1) is deuterium-labeled sildenafil. |
|
V69110 | Sp-cAMPS sodium salt | 142439-95-0 | Sp-cAMPS sodium salt, a cAMP analog, is a potent cAMP-dependent activator of PKA I and PKA II. |
|
V69116 | Sp-cAMPS triethylamine | 93602-66-5 | Sp-cAMPS triethylamine, a cAMP analog, is a potent cAMP-dependent activator of PKA I and PKA II. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
