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    CUDC-427 (GDC-0917)
    CUDC-427 (GDC-0917)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4532
    CAS #: 1446182-94-0Purity ≥98%

    Description: CUDC-427 (also known as GDC-0917) is a novel, potent, orally available, second-generation antagonist of inhibitor of apoptosis (IAP) proteins that is being developed for the treatment of various cancers. GDC-0917 has low to moderate clearance in the mouse (12.0 ml/min/kg), rat (27.0 ml/min/kg), and dog (15.3 ml/min/kg), and high clearance in the monkey (67.6 ml/min/kg). Accordingly, oral bioavailability was lowest in monkeys compared with other species. Based on our experience with a prototype molecule with similar structure, in vitro-in vivo extrapolation was used to predict a moderate clearance (11.5 ml/min/kg) in humans. The predicted human volume of distribution was estimated using simple allometry at 6.69 l/kg. 

    References:  2013 Dec;41(12):2104-13.


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    CUDC-427

    Name: GDC-0917 (CUDC-427)
    CAS#: 1446182-94-0
    Chemical Formula: C29H36N6O4S
    Exact Mass: 564.25187
    Molecular Weight: 564.7
    Elemental Analysis: C, 61.68; H, 6.43; N, 14.88; O, 11.33; S, 5.68
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: CUDC427; CUDC-427; CUDC 427; GDC0917; GDC-0917; GDC 0917;
    IUPAC/Chemical Name: (S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-N-(2-(oxazol-2-yl)-4-phenylthiazol-5-yl)pyrrolidine-2-carboxamide
    InChi Key: HSHPBORBOJIXSQ-HARLFGEKSA-N
    InChi Code: InChI=1S/C29H36N6O4S/c1-18(30-2)24(36)32-23(20-12-7-4-8-13-20)29(38)35-16-9-14-21(35)25(37)34-27-22(19-10-5-3-6-11-19)33-28(40-27)26-31-15-17-39-26/h3,5-6,10-11,15,17-18,20-21,23,30H,4,7-9,12-14,16H2,1-2H3,(H,32,36)(H,34,37)/t18-,21-,23-/m0/s1
    SMILES Code: O=C([[email protected]]1N(C([[email protected]](C2CCCCC2)NC([[email protected]@H](NC)C)=O)=O)CCC1)NC3=C(C4=CC=CC=C4)N=C(C5=NC=CO5)S3


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