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Description: Embelin, a naturally occuring quinone compound isolated from the Japanese Ardisia herb, is a potent and cell-permeable inhibitor of X-linked inhibitor of apoptosis (XIAP) with IC50 of 4.1 μM in a cell-free assay. Embelin was shown to exhibit anti-tumor and anti-inflammatory activity in cells. Additionally, embelin was reported to prevent NF-κB activation by inhibiting IKK and thus resulted in suppression of NF-κB-regulated anti-apoptotic and metastatic gene expression. Treatment of PC-3 cells with 25 and 50 μM of embelin for 48 h, 30% and 75% of cells undergo apoptosis, representing approximately 3-and 9-fold increase as compared to untreated cells.
References: [1] Nikolovska-Coleska Z, et al. J Med Chem, 2004, 47(10), 2430-2440.; [2] Schaible AM, et al. Biochem Pharmacol, 2013, 86(4), 476-486.
Synonym: NSC91874; NSC91874; NSC 91874; Embelin; Emberine; Embelic acid.
Chemical Name: 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
InChi Key: IRSFLDGTOHBADP-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3
SMILES Code: O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS