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Embelin

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InvivoChem Cat #: V0054

CAS #: 550-24-3Purity ≥98%

Description: Embelin is a naturally occuring quinone compound isolated from the Japanese Ardisia herb with anti-tumor and anti-inflammatory activity, acting as a potent and cell-permeable inhibitor of XIAP (X-linked inhibitor of apoptosis) with IC50 of 4.1 μM in cell-free assays.

References: [1] Nikolovska-Coleska Z, et al. J Med Chem, 2004, 47(10), 2430-2440.; [2] Schaible AM, et al. Biochem Pharmacol, 2013, 86(4), 476-486.

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Molecular Weight (MW)	294.39
Formula	C17H26O4
CAS No.	550-24-3
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (200.41 mM)
	Water: <1 mg/mL (slightly soluble or insoluble)
	Ethanol: 12 mg/mL (40.76 mM)
Other info	Synonym: NSC91874; NSC91874; Embelin; Emberine; NSC 91874; Embelic acid. Chemical Name: 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione InChi Key: IRSFLDGTOHBADP-UHFFFAOYSA-N InChi Code: InChI=1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3 SMILES Code: O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Chemical Name	2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione

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In Vitro	Embelin from the Japanese Ardisia herb is a small-molecular inhibitor that binds to the XIAP BIR3 domain with which Smac and caspsase-9 bind. Embelin inhibits cell growth of both PC-3 and LNCap cells in a dose-dependent manner, with IC50 values of 3.7 and 5.7 μM. While, the toxicity of Embelin in normal PrEC and in WI-38 cells is much lower with IC50 values of 20.1 μM and 19.3 μM.
In Vivo	Embelin has also been used extensively in various animal models to study the role of XIAP. In the azoxymethane/dextran sulfate sodium (AOM/DSS) induced colitis-associated cancer (CAC) model, embelin reduced both incidence and tumor size in mice by inhibiting proliferation of tumor epithelial cells and suppressing IL6 expression and IL6-activated STAT3 in vivo.
Animal model	AOM/DSS-induced colitis-associated cancer (CAC) model
Formulation & Dosage	50 mg/kg/day; p.o.
References	Mol Cancer Ther 2014,13:1206-1216.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%
COA
MSDS

Oncol Lett. 2015 Aug;10(2):921-926.

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