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Description: GDC-0152 (RG-7419) is a novel and potent antagonist of IAP (inhibitor of apoptosis) family proteins with antitumor activity. Inhibiting IAPs with Kis of 28 nM, 14 nM, 17 nM and 43 nM for XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 in cell-free assays, respectively; It has lower affinity to cIAP1-BIR2 and cIAP2-BIR2. GDC-0152 is being investigated in Phase 1 clinical trial for cancer treatment.
References: J Med Chem. 2012 May 10;55(9):4101-13.
Related CAS: 873581-21-6 (HCl)
Product Catalog 2023
Guide to Product Handling
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS
NMR