location： Home > Products > Signaling Pathways > Apoptosis > IAP

Birinapant (TL32711)

Price：

Market Price：

This product is for research use only, not for human use. We do not sell to patients.

Number： - + Pieces（InventoryPieces）

InvivoChem Cat #: V0051

CAS #: 1260251-31-7Purity ≥98%

Description: Birinapant (TL32711; TL-32711; TL 32711) is a novel and potent bivalent peptidomimetic of SMAC (second mitochondrial-derived activator of caspases) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins. It has potential anticancer activity. Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with a Kd of<1 nM in a cell-free assay, and is less potent to XIAP.

References: Breast Cancer Res Treat. 2013 Jan;137(2):359-71.

Customer Validation

Top Publications Citing Invivochem Products

Bulletin Board Product Catalog 2023

Bulletin Board

详情页公告 Guide to Product Handling

Publications Citing InvivoChem Products

Physicochemical and Storage Information
Protocol
Quality Control Documentation
Related Biological Data
Customer Review

Molecular Weight (MW)	806.94
Formula	C42H56F2N8O6
CAS No.	1260251-31-7
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (123.9 mM)
	Water:<1 mg/mL (slightly soluble or insoluble)
	Ethanol: 55 mg/mL (68.1 mM)
Solubility (In vivo)	15% Captisol: 15mg/mL
Synonym	TL32711; TL-32711; TL 32711; SMAC mimetic; Birinapant
Chemical Name	(2S,2'S)-N,N'-((2S,2'S)-((3S,3'S,5R,5'R)-5,5'-((6,6'-difluoro-1H,1'H-[2,2'-biindole]-3,3'-diyl)bis(methylene))bis(3-hydroxypyrrolidine-5,1-diyl))bis(1-oxobutane-2,1-diyl))bis(2-(methylamino)propanamide)

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
- Mass
- Concentration
- Volume
- Molecular Weight *
- =
- ×
- ×
The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂
- Concentration _(start)
- ×
- Volume _(start)
- =
- Concentration _(final)
- ×
- Volume _(final)
- ×
- =
- ×
- C1
- V1
- C2
- V2

In Vitro	Birinapant binds with XIAP and cIAP1 with Kd of 45 and<1 nM, respectively. Birinapant induces cell death as a single agent in TRAIL-insensitive SUM190 (ErbB2-overexpressing) cells (IC50, ~300 nM), and significantly increases potency of TRAIL-induced apoptosis in TRAIL-sensitive SUM149 (triple-negative, EGFR-activated) cells. Birinapant causes rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. Birinapant in combination with TNF-α(1 ng/mL) inhibits the growth of human melanoma cell lines WTH202, WM793B, WM1366 and WM164 with IC50s of 1.8, 2.5, 7.9 and 9 nM, respectively.
In Vivo	Birinapant (30 mg/kg) treatment significantly induces abrogation of tumor growth in melanoma xenotransplantation models 451Lu with.
Animal model	Human melanoma xenografts 451Lu
Formulation & Dosage	12.5% Captisol in distilled water; 30 mg/kg; i.p. 3 times per week
References	[1] Krepler C, et al. Clin Cancer Res, 2013, 19(7), 1784-1794.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Lot#: V005101,Purity ≥98%
COA
MSDS
NMR

	Krepler C, et al. Clin Cancer Res, 2013, 19(7), 1784-1794.	Krepler C, et al. Clin Cancer Res, 2013, 19(7), 1784-1794.

Home Prev Next Last page / pices

发评论

Your information is safe with us. * Required Fields.

Product name

Cat

Applicant name

Email address

Phone number

Organization name

Country

Requested quantity

Remarks