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Description: Xevinapant (formerly Debio1143; AT-406; SM-406, ARRY-334543) is a first-in-class and orally bioavailable peptidomimetic of SMAC (second mitochondrial-derived activator of caspases)/DIABLO with potential antitumor activity, also an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase) proteins. It acts by binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Kis of 66.4 nM, 1.9 nM, and 5.1 nM, respectively.
References: Cancer Res. 2004 Oct 15;64(20):7183-90.
Related CAS: 1071992-57-8 (HCl salt) 1071992-99-8 (free base)
Product Catalog 2023
Guide to Product Handling
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Purity ≥98%
COA
MSDS
NMR